Posts Tagged ‘pregnancy’

Radiation Exposure in Pregnancy

Friday, June 17th, 2011

Safe level of radiation for fetusNothing causes panic like the words “radiation exposure”. The earthquake and tsunami that devastated Japan also caused major damage to several nuclear reactors and have magnified our fears about the risks of radiation poisoning.

Radiation studies from past catastrophes such as Hiroshima and Nagasaki, (1946) Three Mile Island, (1979) and Chernobyl, (1986) have helped us determine the amount of radiation exposure that is considered safe. Still, many of the answers have yet to be determined, especially for pregnant women. Therefore, I thought it important to share some information about radiation exposure with specific regard to the fetus and pregnancy.

1) How is radiation released in a nuclear reactor?

Nuclear reactors use uranium or plutonium to produce energy that heat water to steam which turns turbine generators. Radioactive by-products are released in the process of producing this energy. The core, where this energy is created, has a cooling system surrounded by a steel canister and a surrounding concrete envelope. When damage occurs to a nuclear reactor the cooling system can get damaged and the surrounding protective structures can be damaged by explosions and elevated temperatures. The radioactive material in the core can then escape releasing radioactive material into the environment.

2) Who will be affected by the release of radiation?

Exposure can occur directly to employees or emergency individuals who work within the plant itself. Skin and/or deep internal organs can be affected depending upon dosage and type of radiation released.

Radioactive products can also leave the plant and reach people living in the surrounding region. Both skin or internal organs can be involved depending upon dosage and type of product released.

Internal contamination occurs when radioactive by-products are ingested from contaminated water, fruits, vegetables, and seafood inhaled, or enter the body through an open wound. Large numbers of individuals can get radiated in this fashion.

3) Why is radiation dangerous?

Radiation exposure can cause DNA damage resulting in death of cells. Mutations can alter developing cells or cause changes in reproductive cells which can get passed onto future generations. This damage can have both short and long term effects on every organ system in the body. Results can be manifested as deformities, congenital malformations, fetal loss, stillbirths, infant deaths, stunted growth, abnormal brain development, or cancer later on in life. Damage is dependent on the type of radiation, the dosage, length of time of exposure, the particular tissue exposed, and the depth of penetration.

Babies have some added protection being shielded inside the mother so their radiation exposure is less.

4) How is radiation dosage measured?

Radiation is measured in rads, the amount of energy deposited per kilogram of tissue. Gy is also used which refers to the absorbed dose and Sv (sievert) or the effective dose (the absorbed dose multiplied by the sensitivity of tissues and the biologic effect of different types of radiation)

One hundred rads is equal to 1 Sv or 1 Gy

5) What are some of the typical dosages of radiation that people are normally exposed to?

Chest x-ray .01 mSv (.02-.07 mrads) per film
CT of the chest 7 mSv (less than 1 rad)
Mammogram 7-20 mrad
Barium enema 2-4 rads
Crew on an airline flight (annual) 2 mSv
Passenger on an airline flight .07 mSv
Emergency workers in chernobyl >100mSv
Person living at boundary of Three Mile Island >1mSv

Reference: ACOG Committee opinion: Sept 2004; NEJM April 2011


6) Is exposure to x-ray or imaging procedure during pregnancy safe?

Exposing a pregnant woman to diagnostic x-ray procedures should only be performed when the benefits outweigh the risks. A single x-ray procedure does not warrant any significant risk to the fetus according to the American College of Radiology. If multiple x-rays are warranted, dosages of total exposure can be calculated by a specialist. Risks are related to dosage and to gestational age of the fetus.

It appears that exposure between 8 to 15 weeks provides the greatest risk, especially for central nervous system defects.

Procedures with less than 5 rads, as in most diagnostic procedures, generally are not considered problematic.

It is estimated that exposure to 1 to 2 rads can increase the risk of leukemia by 1.5 to 2 fold.

Radiation exposure during the first 2 weeks of pregnancy mostly carries a risk of fetal death if  greater than 100 mGy or 10 rads since organ formation occurs afterward (3 to 5 weeks post conception).

Radiation exposure between 2 and 18 weeks is the most critical time because of the high radiation sensitivity of the developing central nervous system which can be severe. Results from studies of atomic bomb survivors demonstrated mental retardation, lower IQ scores, skeletal anomalies and other birth defects.

Exposure from 18 to 25 weeks can have similar effects occur similar to those previously described when the dosages are extremely large.

After 26 weeks, the risk is mostly the increased chance of having cancer later on in life rather than birth defects. The cancer most commonly observed is leukemia.

Imaging procedures using ultrasound and magnetic resonance imaging (MRI) should always be used preferentially over x-rays since there are no known adverse effects. Use of radioactive iodine is contraindicated in pregnancy. If a woman has been exposed to radioactive iodine, she should wait 4 to 6 months before trying to conceive.

Are X-ray machines at the airport safe during pregnancy?

The x-ray machines at the airport are shielded and there is no increased risk to pregnant passengers.

Are tanning beds dangerous to the fetus?

Tanning beds use concentrated ultraviolet A radiation which is very superficial and does not penetrate through the skin to the fetus. It is therefore considered safe in pregnancy.

Is it safe for pregnant women to fly?

Commercial flights expose passengers to cosmic rays in the atmosphere. Flights at latitudes close to the magnetic poles, such as international flights between Canada and European countries have radiation doses that are higher in comparison to short-distance flights at lower altitudes and latitudes. Calculations of radiation received during a flight can be calculated using the website http://www.helmholtz-muenchen.de/epcard

It is recommended that cosmic radiation dose to a fetus not exceed 1 mSv , or 2 mSv to a woman during the entire pregnancy. A pregnant air flight attendant may have to modify her schedule to ensure that this requirement is met. Generally, during a commercial flight the average dose of radiation to a fetus is 5.28 uSv (this is half the dose that the mother receives). A pregnant crew member can travel by air for approximately 190 hours during the entire pregnancy safely. The 2 mSv limit would be exceeded after 8 round trip flights from Canada to Germany.

It can be assumed that the casual traveler has minimal radiation exposure when traveling by air during pregnancy.

Summary:

Radiation risks are determined by a combination of stage of pregnancy and dosage. Significant risks occur when organs are forming and decrease with each trimester.

Dosages below 50 mGy, 10 mSv or 5 rads are considered safe.

Termination of pregnancy might be considered for dosages of radiation between 100 and 500 mGy, based on individual circumstances.

Dosages above 500 mGy have been found to have significant fetal damage.

Further research is necessary to determine if chronic lower dosages may also cause significant effects.

Central nervous system is particularly sensitive between 8 to 15 weeks to radiation effects.

Important diagnostic procedures involving radiation can be done if the benefit far outweighs the risks, but MRI and ultrasound should be done preferentially.

Lead shields can be worn during an x-ray procedure to reduce exposure to the fetus.

Color Me Safely: Hair Dyes In Pregnancy

Monday, March 7th, 2011
When it comes to your own personal grooming, is there anything more satisfying than being crowned with a head of thick, shining hair? Do you divide your life into good hair days and bad ones? Does a bad hair day leave you depressed and lethargic while a good one propels you through glass ceilings. Guess what? You are not alone!

Hair being dyed

According to Hoovers® there are about 65,000 hair care salons in the United States with combined annual sales of about $19 billion! A small portion of these sales are for hair cuts, but most of this money is spent on… hair color.

If you are pregnant, planning to get pregnant or if you have a job in one of these salons, please read the following carefully: Over 20 million Americans, mostly women, are exposed to hair dyes each year. It has been estimated that at least 35 to 40% of all women in the United States and Europe use hair dyes. Solutions are applied either by a salon hairdresser or by individuals purchasing over the counter products.

According to the International Agency for Research on Cancer (IARC), concerns exist pertaining to the safety of these products. Why? Because some of the ingredients in hair dye are considered to be carcinogenic and teratogenic (causing malformation in fetuses). Reports of hairdressers having increased risk of spontaneous abortion, congenital malformations, childhood cancer and developmental problems exist. Older literature from the 1980’s report that men and women exposed to hair dyes in their occupations may experience increased risk of developing leukemia and cancers of the bladder, ovary, GI tract, and respiratory systems. Nasca, reported in the Journal of the NCI, that there is a higher risk of breast cancer in women that use hair dyes.

Pregnant women throughout the world who commonly use beauty products worry about the risk of exposure to themselves, and to their fetus, because of the potentially carcinogenic chemicals contained in these products. Many women are hesitant to use dyes during pregnancy due to fears regarding chemical use and absorption with risks to the fetus.

More concerning is the fact that many women are giving birth at later ages and therefore the use of hair dyes will become increasingly more popular. The combination of hormonal hair growth increase during pregnancy, and the increased need for coloring as a woman ages, obviously predicts an increased use of these products.

With all this in mind, I thought it would be a good idea to write a blog that reviews the literature to date regarding the safety concerns of hair dyes so that you can make the right decision, for yourself, about whether or not to use these products. Overall conclusions, however, should be based upon the method of dye application (personal vs hairdresser), the colors used, the frequency of coloring, and the differences between varying product components available on the market.

How are hair dyes classified?
There are three classifications:

  • Permanent,
  • Semi-permanent
  • Temporary

Chemical composition of the hair dye determines in which classification it is placed

Permanent dyes are the most prevalent and comprise about 75% of all hair dyes. They act by oxidation with hydrogen peroxide of dye precursors that permeate the hair fiber producing the color associated with the dye. Permanent hair dyes are commonly applied with a brush and by a hairdresser. Permanent hair dyes allow more dramatic changes in hair color. They do not wash out and they last until the hair grows or is cut.

Semi-permanent dyes comprise approximately 20% of all dyes and directly penetrate the hair cortex without the use of oxidizing agents. Generally the color lasts between 6 and 12 washings. These dyes, often applied by hand, are mostly used to cover gray or highlight the natural color, and are often purchased over the counter.

Temporary dyes, comprising about 5% of all hair dyes and are used for a single wash. This hair coloring is deposited on the cuticle layer of the hair and remains until shampooed out. It generally will not lighten hair but used to intensify natural color, tint hair another color, or add highlights to natural or tinted hair. It is also used to cover a limited amount of gray hair or eliminate yellowish shades from white or gray hair.

Which hair dye chemicals raise concerns in pregnancy?
Several reported studies have shown an increased risk of childhood brain tumors (CBT) associated with exposure to N-nitroso compounds, commonly found in hair dyes.

There are 2 broad classes of the N-nitroso compounds

  1. nitrosamides
  2. nitrosamines

Nitrosamides are unstable and do not require enzymatic activation and are inclined to tumor formation at the exposure site. In rats, they cross the placenta and are neurocarcinogens.

Nitrosamines ,commonly found in tobacco smoke and beer, are considered carcinogenic agents.

Chemicals found in hair dyes are aromatic amines which get converted into nitrosamines. Nitrosamines, require this bioactivation and can initiate tumor formation in places at locations other than the initial exposure site. Hair dyes are considered NOC-related aromatic amines and contain ammonia based solutions, hydrogen peroxide, coal-tar dyes, and lead acetate. Many studies classify these agents as carcinogenic in animals when dosed orally because they alter DNA, but there exists “inadequate evidence” to determine carcinogenicity in humans when applied topically.

Other toxic chemicals found in hair dyes include phthalates, cobalt salts, formaldehyde releasing preservatives, lead acetate, nickel salts, 1,4-dioxane, diethanolamine/triethanolamine, and parabens.

How does exposure to the fetus occur when a pregnant woman uses hair dyes?
Exposure to the fetus occurs during routine use since many of the chemicals used are skin permeable. The particular characteristics of the dye products and their ability to penetrate skin influence their toxicity. Exposure can also occur via ocular, oral, or inhalation routes which can then cross the placenta and affect the fetus. Many of these chemicals can also be stored in body fat and also enter the mothers milk.

What type of toxicities have been described in pregnancy?
There have been many inconsistent results between use of hair dyes and various childhood cancers.

Some studies have shown an association between maternal hair dye and elevated risk of childhood cancer. The immature nervous system of the fetus has been found to be especially vulnerable to carcinogens and mutagens. If exposure occurs during the development of the nervous system during the first trimester, this may make the nervous system more susceptible to cancer and brain tumors.

Neuroblastoma, comprising about 6 to 10% of all childhood tumors in the developed world, is one of the most common cancers in children during the first year of life. A 3 fold increased risk was found in children of women exposed to hair dyes during pregnancy according to an article written by Kramer in the Journal of the National Cancer Institute in 1987. This increased risk is also confirmed by McCalls article in 2005 in Cancer Causes and Control. Wilms tumor, a cancer of the kidneys in children, had a 4 fold increased risk according to a study by Bunin in Cancer Research in 1987. Many of the chemicals used in 1987 in hair dyes have since been discontinued (2-4-diaminoanisole, 4-amino-2 nitrophenol, and HC Blue No.1) but other chemicals in the N-nitroso aromatic amines commonly used in hair dyes are still present which are carcinogenic in animals.

Other studies from the West Coast have found no association with hair dye use before or during pregnancy. (Holly in Pediatric Perinatal Epidemiology, 2002) One large study by Effird in Journal of Neuro-Oncology in 2005 also confirmed no statistically significant association between temporary, semi-permanent, or permanent hair dyes during pregnancy and childhood brain tumors, except for a 3 fold higher incidence of for brain tumor among Israeli children using semi-permanent hair color.

Do different types of hair dyes present different levels of risk?
Temporary dyes (includes semi-permanent) appear to have more toxicity than permanent dyes in pregnancy. Studies of scalp penetration of semi-permanent dyes compared to permanent dyes in both humans and monkeys found that semi-permanent dyes penetrated the scalp more than permanent dyes in both species. Unlike permanent dyes that contain oxidizing agents that allow the dye to irreversible bind to the hair shaft and therefore has lower skin absorption, semi permanent dyes achieve their coloring action via the use of various solvents (alcohols and ethylene glycol ethers) which penetrate the scalp more efficiently compared to permanent dyes. Also, greater skin contact occurs with semi-permanent dyes since they are applied as foam, rinse or surfactant solutions which tend to facilitate uptake by the skin. Semi-permanent hair coloring products also contain nitro derivatives of phenylenediamines or aminophenols, azo dyes and aminoanthraquinone dyes and N-nitroso compounds that have been shown to be transplacental neurocarcinogens in rodents.

Also, semi-permanent dyes are more likely applied by the person herself whereas permanent dyes were more likely applied by a hairdresser. With self-application there is more exposure to skin surface, such as hands, than if an outside person did the applications.

Smokers were also found to have greater toxicity than nonsmokers with dye use. Added exposure to nitrosamines and other carcinogens in cigarette smoke added to those carcinogens present in the hair dyes.

Do hairdressers have added risk?
The occupation of being a hairdresser may entail some risks that are possibly carcinogenic.(International Agency of for Research on cancer-IARC-1993) Certainly skin disorders like contact dermatitis and occupational asthma are major health problems for hair dressers. Other studies have not supported increased risk of reproductive disorders among hairdressers, such as infertility, reproductive loss, congenital malformations, childhood cancers, and developmental disorders in offspring. (Kersemaekers, 1995)

Summary:
Limited human data, inconsistent results, and differences among products with varying chemical formulations used make it impossible to draw conclusions on safety. Differences in duration of exposure and amount of exposure can also determine differences in toxicity. Overall, many studies support no consistent association of congenital anomalies with hair dyes after many of the regulated carcinogens were removed. However, risk cannot be completely excluded so precautions should be taken.

There does appear to be some difference between the use of permanent and temporary hair dyes in pregnancy. Risk seems to be higher for mothers using semi-permanent dyes at any time during pregnancy, or the months prior to pregnancy, compared to the other types of hair dyes used.

Hair dye formulations have changed over time with removal of some substances and inclusion of new and better ones for color range. There has been a reduction in certain nitrophenols. The FDA has discontinued use of 2,4-diaminotoluene, and 2,4-diaminoanisole in permanent dyes and HC Blue No 1 and 4-amino-2-nitrophenol used in semi-permanent dyes because of possible carcinogenic effects.

It is imperative that pregnant women reduce their level of exposure, especially during first trimester. If dyes are going to be used, using protective gloves and facial mask, using a well-ventilated room, avoiding eating or drinking during exposure, and avoiding frequent exposure are essential. Avoid chemicals that may enhance absorption into the scalp or the hair shaft.

If one chooses to use hair dyes, it is generally recommended to wait until after first trimester when most of the baby’s organ systems have been formed. If you must dye your hair during pregnancy, ask your stylist to use the old fashioned method — a plastic cap with tiny holes to pull the hair through. Dying the strands in this manner will prevent the chemicals from contacting your scalp, reducing the absorption risks.

Once again, this information is provided so that you can make the best decision for yourself and your baby. Consult your obstetrician for further information.

How to Stop Heartburn During Pregnancy

Friday, February 4th, 2011

Heartburn in PregnancyThis is the second half of my blog regarding heartburn in pregnancy. The first half explained the causes and symptoms and together, hopefully, will quickly help you solve the burning symptoms of heartburn should they arise.

Therapy
As in most other conditions during pregnancy, behavioral modifications are always attempted initially. Drug therapy is reserved for the more severe cases. Avoidance of all medications during the first trimester, unless absolutely essential, is always considered sound advice.

  1. Lifestyle Changes
  2. Drug Therapy
    1. Antacids: The treatment of choice. The antacids neutralize the acid of the stomach juice and thus prevent its caustic effects on the lining of the esophagus.
    2. Sucralfate: Sucralfate, (Carafate- 1 gram three times a day), similar to antacids, is an aluminum salt that inhibits gastric acid, and does not get absorbed. It is considered safe in pregnancy and in breast-feeding women.
    3. GI Stimulant or Prokinetic agents: Metoclopramide is a drug that raises lower esophageal pressure and is also an anti-emetic. It is very effective in controlling heartburn of pregnancy and considered safe in pregnancy. A recent study in The New England Journal of Medicine by Matok concluded that metoclopramide in the first trimester was not associated with increased risks of any major congenital malformations, perinatal death, preterm birth, low birth weight, or low Apgar scores.
    4. H2 Receptor Blockers: (Pepsid and Axid, Cimetidine, Famotidine, and Nizatidine) The drugs in this category inhibit gastric acid secretion. These drugs are used in women with severe heartburn. Even though animal studies have not shown any adverse effects of the fetus, very little data is available in humans. These drugs should therefore be avoided in pregnancy if possible.
    5. Proton pump inhibitors: (Prilosec, Lansoprazole) Similar to H2 Blockers, these drugs also block gastric acid secretion. These drugs are more effective and have more rapid onset of action in relieving the symptoms of GERD compared to H2 receptor blockers. Two recent articles, one published by The American College of Gastroenterology by Gill in 2009 and another published by New England Journal of Medicine in 2010 by Pasrternick confirmed the safety of the use of Prilosec during pregnancy. Further studies need to be done to determine the safety of use during lactation and also risks with other drugs in this category.

In summary: Reflux is common in pregnancy. In most cases the condition responds well to lifestyle changes. More severe cases may require drug therapy. Antacids alone or in combination with alginic acid used after meals or at bedtime provide excellent relief in most cases.  In refractory cases, H2 receptor blockers should be considered but used sparingly (once a day rather than twice a day) after dinner. PPI’s as of recent data have now also been proven to be both safe and effective drug therapy.

Women suffering from heartburn should be reassured about the temporary nature of this condition and the fact that it will not affect the well being of the growing fetus.

Active management of heartburn can improve the pregnant woman’s quality of life.

Pregnancy, Holiday Stress and You!

Wednesday, December 15th, 2010
The season of joy can indeed be joyous, but for most people it also means cramming enormous amounts of activity into a tiny amount of time. While Holiday gift shopping and business and social celebrations are fun, they arrive with the need to prepare large meals, deal with relatives and in-laws, worry about the cost of new clothes and extra food, end of year taxes, finances in general, bonus anxiety and even job security. This kind of pressure can  bring on enormous amounts of stress and will drive you nuts (not the warm chestnut kind) very quickly if you let it.
For mothers-to-be, how does all of this stress affect her pregnancy? Can maternal psychiatric conditions such as depression, anxiety, and stress adversely affect the baby when pregnant during the holiday season? This particular area of concern has always been debatable but review of recent scientific literature has shown some surprising results regarding the relationship between psychiatric conditions and the possibility of affecting the uteroplacental environment… and consequently the fetus.

Is there evidence that psychiatric conditions can effect pregnancy outcome?

A recent article from the Journal of Affective Disorders, in 2010 by Nicole Paz found that the risk of placental abruption is increased in pregnant women with mood or anxiety disorders. Placental abruption is an obstetrical emergency when the placenta prematurely separates from the wall of the uterus. This occurs in about 1 to 2% of all pregnancies. It is often associated with an “ischemia of the placenta” or a lack of perfusion to the placenta causing parts of the placenta to be infarcted (deadened) and consequently separate from the wall of the uterus. The placenta is the lifeline to the baby and having substantial areas that no longer function can dramatically effect the safety and well-being of the baby. Many other medical situations can be associated with this event such as hypertension, uterine infections, trauma to the uterus, premature rupture of membranes, maternal smoking, and maternal clotting disorders. Now there might be evidence that psychiatric conditions can also effect the placenta.

Previous studies by Qiu in 2009 have shown that there is a higher risk of preeclampsia (hypertension, protein in the urine , and marked swelling) and preterm delivery with maternal depressive, anxiety and stress symptoms. The authors Alder in 2007, and Halbreich in 2005 confirmed that anxiety during pregnancy and psychological distress have been reported to be associated with preterm delivery, low birth weight, and obstetrical complications. Another scientist Cohen in 1989 described placental abruption associated with panic attacks.

What is the mechanism by which this occurs?

Activation of the sympathetic nervous system with elevated chemicals in the body such as cortisol, corticotrophin releasing hormone, and serotonin levels, associated with anxiety and stress is believed to cause some of these observations. Stress causes increased hypothalamic—pituitary-adrenal activity. These elevated chemicals can result in systemic inflammation and damage to vessel lining (endothelial dysfunction) which can lead to abruption of the placenta. Other investigators have found changes in clotting and platelet activity in women with major depression which can then affect coagulation pathways resulting in preeclampsia and abruption. Much evidence has mounted to show a relationship between depression and cardiovascular disease later in life through similar mechanisms.

More studies need to be done to investigate all the hormonal, vascular, and hemodynamic effects of maternal mood and anxiety on pregnancy and its outcome.

Is there evidence that psychiatric conditions occurring during pregnancy can effect mothers after they deliver?

Research has shown that anxiety, depression, and prenatal stress is also associated with maternal mental disorders after birth. There is a higher incidence of postpartum depression in women that have prenatal anxiety.

Is there evidence that psychiatric conditions during pregnancy can effect the emotional state of children after they are born?

Behavioral and emotional problems in children such as attention deficit disorders, hyperactivity, oppositional defiant disorder and childhood anxiety are more prevalent in mothers that have anxiety and psychological distress during their pregnancies.

Summary

Maternal anxiety and stress during pregnancy can negatively affect both mom and baby both during the pregnancy and afterward. Screening women that have some of these disorders, and providing treatment, could be found to alter some of the adverse pregnancy outcomes associated with some of these well known psychiatric illnesses.

In the meantime, try to chill out during THIS holiday season. Allow yourself to sit back, and let everyone else worry about the seasonal details. No gift, meal, or gathering should ever be allowed to get under your skin because you don’t want stress to get the better of your baby’s health.

Get some relaxation tapes, try a little yoga and/or meditation and treat yourself to a massage—DOCTORS ORDERS!!

Please accept our best wishes for a happy, healthy and stress-free Holiday Season.

Dr. Michele Brown & the Beauté de Maman Team

Lobster Tales & Other Stuff to Know About Thanksgiving

Tuesday, November 23rd, 2010

Thanksgiving is a special holiday of reflection, especially for pregnant women. It is a time of gratitude for our health and happiness with those family and friends who have meant the most in our lives.

The holiday started in 1621 as a gathering of the Pilgrims in celebration of a successful and bountiful harvest to be shared with the Wampanoag Indians who were instrumental in their survival in the New World. The Pilgrims were originally members of the English Separatist Church who fled from England to Holland due to religious persecution. The Dutch were more tolerant, but the Pilgrims left for the New World for a better moral life. A total of 102 people sailed on the Mayflower, but after the first winter, 46 had died due to disease and famine. With the help of the Indians, the settlers survived the following winter with a bountiful harvest and commemorated their success with a 3 day feast.

Due to the insistence of a magazine editor, Sarah Joseph Hale, whose never ending editorials in Boston Ladies magazine, Godey’s Lady’s Book and letters to politicians, the Thanksgiving holiday was made official more than 242 years later by President Lincoln. In 1939 President Roosevelt moved Thanksgiving from the last Thursday in November to the second to last to extend the Christmas shopping season. Some states went along, some didn’t, creating confusion since it was not a consistent holiday for members of families that lived in different states. This went on until December 1941 when congress (prompted by public outcry) moved it back to its original last Thursday in the month of November.

The food that was eaten for the first celebration back in 1621 was undoubtedly very different from what we commonly see on the modern day Thanksgiving table. They most likely did not have turkey, but rather deer, fowl, lobster, clams and cod. The traditional pumpkin pie, mashed potatoes, apple cider, milk or butter were also not present. There were no breads or pastry since supplies of flour and sugar were long gone. Items such as pumpkin, turnips, peas, onion, beans, watercress, berries, plums, grapes, and dried fruit were more likely seen.

In 1621, no forks were present and the tablecloth served as not only as a present day napkin but as a way to pick up hot food. The most important people sat next to the best food. Contrary to today’s large platters of food that are passed down the table, people ate only what was closest to them.

In conclusion, we from Beauté de Maman wish all a happy and healthy holiday. We end this blog with a special prayer for the beginning of the holiday season.

Blessed are You, Lord our God, King of the universe, who has granted us life, sustained us, and enabled us to reach this season.

Pregnant for the Holidays: To Toast or Not to Toast?

Wednesday, November 17th, 2010
Pregnant woman with a glass of wine

Is drinking during pregnancy risky for your baby?

You are all dressed up and ready to leave for the annual holiday party at your office, at your neighbor’s home, or maybe with family. The holidays are so special, festive and romantic, but this year there is a heightened sense of excitement because… you are pregnant.

With the holidays rapidly approaching, the age old question raises itself along with the clink of glasses — can I join in the festivities with family and friends by having an alcoholic drink to celebrate. Maybe just one?

The general rule has always been to avoid alcohol in pregnancy. The prevalence of alcohol use in pregnancy is estimated to be roughly 12.2% with 1.9% reporting binge drinking. Women have been shown to have a tendency to underestimate their alcohol consumption during pregnancy which often underestimates the fetal exposure also. Factors associated with alcohol use in pregnancy include education level, income level, temptation to drink in social situations, previous drinking history prior to the pregnancy and history of drinking at initiation of prenatal care.

High levels of chronic heavy prenatal alcohol consumption or frequent heavy intermittent use is a known cause of birth defects commonly referred to as Fetal Alcohol Syndrome. Among the characteristics of this condition are:

Moderate levels of alcohol consumption (1–2 drinks per day) during pregnancy can be associated with milder but clinically significant outcomes such as childhood cognitive, learning, attentional, and behavioral problems.

Prenatal alcohol consumption, even at levels of less than one drink per day, may adversely affect fetal growth and development.

The question always arises — is there a safe level of drinking during pregnancy? (less than 1 drink per week?) It has been clearly found that heavy drinking harms a child’s health and development but the role of light drinking has been far more controversial.

This issue is also relevant since in most industrialized countries, women of childbearing age drink alcohol and often this happens in the first trimester prior to pregnancy being recognized.

The mechanism of how alcohol acts as a toxin varies from direct alcohol toxicity, to placental dysfunction, fetal hypoxia, acetaldehyde toxicity, and nutritional deficits. The area of the brain that is commonly affected by alcohol is the hippocampus and development of the cerebral cortex.

What determines toxicity is the concentration of alcohol used, the pattern and quantity consumed and the stage of development of the fetus.

How much drinking is considered harmful for pregnant women?

Some studies that have reported an association between very low levels of prenatal alcohol exposure and fetal growth, but the the association has not been consistent.

A recent article from the Journal of Epidemiology and Public Health in 2010 by Kelly studied data from 11,000 British children born from 2000 to 2002 found that cognitive deficits and problem behaviors at age 5 were less common among children exposed to light amounts of alcohol (1 or 2 drinks a week during pregnancy). In other words, light drinking may not be as risky for a child’s early development as originally feared.

Robinson in the British Journal of OB/Gyn in 2010 also did studies that showed that light drinking (2–6 drinks per week) of alcohol in pregnancy was not a risk factor for child behavioral problems, although this study did not observe physical developmental outcomes.

The British Journal of OB/Gyn in 2007, Henderson also found no convincing evidence of adverse effects of prenatal alcohol exposure at low-moderate levels on consumption of less than 84 g of alcohol per week (1/2 pint of ordinary beer or lager contains 8 grams of alcohol and an ordinary glass of wine contains 12 g of alcohol). His study demonstrates that low levels of alcohol consumed during pregnancy, less than 60 g/week and not more than two standard drinks per occasion, were not associated with preterm birth or SGA infants.

O’Leary authored an article in the journal, Pediatrics in 2009, in which he also did not find an association between low levels of prenatal alcohol consumption and language delay at any period of time in a child’s development, compared to mothers who engaged in heavy or binge drinking. He used language development as a significant milestone for children as he took the position that delay in that area might indicate further delay in a child’s overall development.

In contrast, in Pediatrics in 2007, Sayal studied 12,678 pregnant women in England to determine whether very low levels of alcohol consumption during pregnancy (less than 1 drink per week) are independently associated with childhood mental health problems between 4 and 8 years of age. His conclusion was affirmative that during early pregnancy these low levels may have a negative impact and persistent effect on mental health outcomes. The developing brain in the first trimester may be especially vulnerable. However, alcohol use before the pregnancy was not associated with adverse outcomes. The other surprising finding was that girls seem to be more vulnerable to the effects of low levels of alcohol compared to boys although this may be a chance finding.

The American College of Obstetrics and Gynecology and the American Academy of Pediatrics continue to feel that no amount of alcohol is safe during pregnancy.

In summary:

The exact safety threshold for the amount of alcohol is unknown, therefore the best advice is to avoid alcohol entirely. There is no established safe level of prenatal alcohol use, which has led to the recommendation of total abstinence. All clinicians taking care of pregnant women should routinely ask about exposure to alcohol during pregnancy. On the the other hand, the data shows that women who have conceived unexpectedly while drinking small quantities of alcohol, should be reassured that they have not placed their unborn child at increased risk of behavioral problems.

Finally, questions concerning a spouses drinking patterns are also important. It has been found that expectant fathers, or partners, could have a major impact on a pregnant woman’s health habits. The expectant father could be an influential modifier of prenatal behaviors. Social support is directly related to the extent of alcohol use in pregnancy. Screenings, assessment and intervention with a partner can effectively reduce antenatal alcohol use and minimize fetal risk.

The Importance of the First Prenatal Visit

Tuesday, November 9th, 2010
OB/GYN Prenatal Visit

Come in to see your OB/GYN as soon as you think you're pregnant. Honestly, there is nothing more important for getting you and your baby off to a great start!

You just found out you’re pregnant! You rush to call your husband, then your mother, email your Aunt Annie and text your BFF. Excitement, celebration, hugging and kissing!

But before the excitement cools, there’s still one more person that wants to hear your good news… your OB/GYN.

Don’t delay. Here’s why.

The purpose of prenatal care is to optimize the chances of a healthy baby while ensuring the physical and emotional health of the mother. In order to best accomplish this, it is essential that there is early initiation of the first prenatal visit. Reports from Center for Disease Control have shown that delayed or no entry into prenatal care can result in a higher rate of complications with resultant severe maternal morbidity and or mortality. In addition, for the baby, studies have shown a direct association between early comprehensive prenatal care and increased birth weights.

What are some of the important reasons for having an early prenatal visit?

  • Establish more accurate dating
  • Counsel and educate patients about diet and exercise
  • Obtain a detailed medical history and physical so medical conditions both current and from previous pregnancies can be detected and managed early in the pregnancy
  • Discussions about avoidance of dangerous medications and harmful habits such as smoking, drinking, and the use of drugs
  • Detect early signs and symptoms of miscarriage or possible ectopic pregnancy

Unfortunately, recent studies have shown a trend that women are delaying the scheduling of their first prenatal appointments.

Several reasons why pregnant women delay early care:

  • Mothers sometimes avoid scheduling early appointments due to non-recognition of the pregnancy
    Over the counter pregnancy tests are extremely accurate so make sure you know the signs of early pregnancy. It’s very easy to ignore these signs but it’s very important that you are seen before the fetus begins developing.
  • Difficult work schedules
    Inform your employer that you are pregnant. Perhaps they can help rearrange your work schedule to find time for your very important prenatal visits.
  • Financial considerations
    Ask the physician’s billing department if the practice offers terms for newly pregnant families. Make sure you understand your insurance policy and if not, call your carrier and have them go over your options in detail.
  • Difficulty in the doctor’s office accommodating the new pregnant mother
    If the receptionist can not accommodate an early appointment, make sure the doctor knows you believe you are pregnant. Your doctor may have some slots available for a newly pregnant woman. If you can’t get an appointment with the doctor, ask if they have a physician’s assistance, midwife or a nurse practitioner to initiate your prenatal care. Alternatively, some practices now have Group Prenatal Care for low risk patients and multiple people can be seen together for the preliminary visit. This can be fun, a great way to meet other pregnant women and you can obtain the early, very important information and advice you need.

It has been found that over one quarter of all first prenatal visits are occurring after 8 weeks gestation when all the organ systems have already developed in the fetus and toxins or certain medical conditions have already taken their toll.

If you’re not yet convinced:

In a recent article, Sept 2010 in the American Journal of Obstetrics and Gynecology by Arnold Cohen, a suggestion was made to have a mini-triage system established for all pregnant patients who called the office for a first prenatal appointment by a competent and skilled health care provider. By asking certain key questions that pertain to dating the pregnancy, and known risk factors such as medical illness, medications, and previous pregnancy complications, it can be decided which patients take precedence and require very early initial prenatal appointments and which patients are more routine and can be delayed. In this way, more time and effort can be expended to improve prenatal care to those who most need it. Too often the questions currently being asked revolve solely around patient insurance issues and hospital coverage.

Summary:

In a country that spends 35% of all US infant spending on prematurity and also ranks at the bottom of the developed countries in the world on infant mortality, I think it is very reasonable to try and identify high risk pregnancies very early in the game in the hopes of preventing adverse outcomes through education and careful, frequent monitoring by a qualified health professional right at the very beginning of the pregnancy. In this way, we might be able to see an improvement in prematurity, adverse maternal outcomes, congenital anomalies, and low birth weight infants in the future.

Don’t Let the Flu Bug Your Pregnancy

Wednesday, November 3rd, 2010

Can you believe that flu season has arrived again? Any one of us can be infected, but pregnant women, as stated in our previous articles, are considered to be in the “high risk” group for complications from acquiring the seasonal flu virus. This is due to a suppression of the normal immune system during pregnancy.

Therefore, I want to personally remind all my pregnant readers, regardless of trimester, to get vaccinated prior to the January peak of the flu season. Postpartum women should definitely get vaccinated as well.

The vaccine is safe and serves as a protection both for mother and for the newborn during the first 6 months of life. Children under six months of age are ten times more susceptible to respiratory infections requiring hospitalization compared to older children. By vaccination of mom, maternal antibodies are formed which cross the placenta or appear in breast milk and prevent infection in the newborn. Newborns have a 41% reduction in the risk of acquiring influenza when mothers are vaccinated according to studies from Johns Hopkins.

It is a common misconception that vaccination during pregnancy is not safe. In addition many women view the flu virus as mild, not needing the protection offered by vaccination. Both these facts are misconceptions and have resulted in a poor acceptance of vaccination during pregnancy. Of all the deaths from the influenza virus last year, a disproportionate number were pregnant women. Health care providers in obstetrics have an obligation to educate their patients to accept vaccination since the majority of pregnant women have regular contact with caregivers. In addition, prior vaccination in 2009 does NOT afford protection against this years flu virus and revaccination must occur since new flu virus strains appear each year.

Pregnant women can receive the flu shot only, but breast feeding women are able to receive either the shot or the nasal spray (live weakened virus). Rather than receiving 2 separate shots, this year’s vaccine is a combination of 3 strains—an H3N2 virus, an influenza B virus, and last years H1N1 swine flu. If one should contract a flu virus other than that created for the vaccine, it will most likely result in a milder course.

It should be remembered that allergy to chicken eggs, those that have had a severe reaction to a prior flu shot or developed Guillain-Barre syndrome (type of paralysis after an infectious process) should not receive the vaccine. In addition, it best to wait till after any cold has subsided before vaccinating.

Should pregnant woman contract the flu, treatment with one of the antiviral agents, such as Tamiflu is recommended as soon as you suspect disease. Taking the medication on a full stomach can reduce the most common side effects which are mild nausea and vomiting within the first 2 days of treatment. Tamiflu, given for 5 days, will shorten the duration of the disease and help prevent the serious complications that can occur in pregnant women.

In the meantime, pregnant women should avoid people that are sick, wash their hands often and GET VACCINATED.

Three Simple Rules for Storing Your Breast Milk Safely

Tuesday, August 3rd, 2010

Renate Abstoss IBCLC

Career Woman and BabyWhile life does sometimes becomes a juggling act, most of us have learned how to keep all the balls in the air. For a new mother with a job outside the home, however, the simple desire to continue breastfeeding her baby may seem impossible.

Don’t give up!

It’s a well known fact that breast feeding has significant benefits to both mother and baby. I have written several previous blogs addressing these benefits. Just last week I wrote about how 60% of the 4 million pregnant women in America are currently employed and that the majority of these new mothers will want to return to the workforce soon after delivery. This should not be a deterrent for promoting optimal infant health and therefore, it becomes extremely important for women to be encouraged to continue to breast-feed their newborns in a convenient way while still carrying on their daily work lives. Since women are not available for demand feeding, it is vital they know how to use a breast pump and how to store milk so that another caregiver can provide milk for the newborn. The blog this week will deal with the proper way to store breast milk.

What is the length of time that I can store milk?

Breast milk storage follows the rule of 3:

  1. Freshly pumped breast milk at room temperature (77 degree F or 25 degree C) should be used within 3 hours.
  2. Freshly pumped breast milk that is refrigerated (39 degree F or 4 degree C) should be covered and used within 3 days.
  3. Freshly pumped breast milk can be frozen (4 degree F or -16 degree C) for up to 3 months. (Check your home freezer for temperature—freezers may run as low as 0 degrees F and deep freezes may run at -10 degrees F.)

Can I refrigerate or freeze milk after it has been sitting out for the 3 hours?

No. One cannot follow one step after the other. The milk is at the end of its shelf life after one of the above 3 steps is followed. However, if small amounts of milk are pumped at a sitting, it is possible to put the freshly pumped milk in the refrigerator to cool and then immediately add it to frozen milk in order to obtain the accumulated 4 oz. feeding. The milk will often freeze in layers and needs to be shaken before use. Shelf life is determined by the older milk in the container. Some sources suggest using the milk for longer periods of time, but often the taste of the milk deteriorates due to breakdown of flavonoids, which may cause the baby to reject the milk. The taste deterioration occurs before the milk becomes contaminated due to elevated bacterial counts.

What guidelines should I follow for freezing milk?

Similar to the way food stock is rotated in a supermarket, the newest milk should be placed in the back of the freezer where it is colder and older milk moved to the front, as a reminder to use it first. Dates should be placed on the container. If frozen for storage in a day care center, place the baby’s name on the container. Freezing in small allotments of 2 to 4 oz. is recommended since it takes less time to defrost and less is wasted if the baby is unable to finish the feeding. Leave room at the top of the container when freezing since liquid expands when frozen.

Disposable bags with freezer ties are fine to use since they take up less refrigerator space. Less expensive generic bags are just as good as brand name bags. It is a good idea to double bag the milk to eliminate and risk of contamination due to leakage. Several smaller bags can be placed in a larger zip lock bag. Plastic or glass storage containers can also be used, but there is risk of breakage. Avoid containers that have BPA.

How do I reheat the refrigerated or frozen breast milk?

Milk that has been frozen or refrigerated can be reheated to room temperature by putting it in a cup of hot water or in a bottle warmer. Refrigerated milk may take about 5 minutes to reheat and frozen milk may take about 20 minutes. Frozen milk left in the refrigerator to thaw takes approximately 12 hours. Never microwave frozen or refrigerated breast milk. This will destroy some of the beneficial properties of the milk. In addition, microwaved milk may be unevenly heated which could be potentially dangerous to the newborn. Milk that has been defrosted may appear layered due to the fact that the fat content will rise to the top. You may want to mix the milk by shaking before feeding to the baby.

Where do I get further information on storing pumped milk?

The La Leche League has a website that reviews storage guidelines. Guidelines may vary depending upon the lactation consultant. Also, the Human Milk Banking Association of North America (HMBANA) is a non-profit organization that sets standards and operates human milk banks in Canada, Mexico, and the United States. They provide information to the medical community on the storage of human milk and also serve as a resource for both potential milk donors and recipients for mothers that are unable to provide breast milk. We must keep in mind that there are new mothers who for one reason or another are not able to breast feed (gender, medications, illness, decreased supply, adoption/surrogate birth, etc.) and want the best nutrition and immunity protection for their baby.

Renate Abstoss IBCLC
Born and educated in Austria, Renate sat for the first International Board Exam for Lactation Consultants in 1985 and has been continuously certified and worked in the field since that time. She is currently the Lactation Consultant at The Stamford Hospital, a position she has held since 1997.

Consider purchasing Beauté de Maman Nipple Gel for breastfeeding or breast-pumping mothers. Safe for baby.

Don’t Let the Marks On Your Body Define You!

Tuesday, July 13th, 2010

Stretch Marks During Pregnancy

In the past

Stretch Marks or Ferocious Tiger Stripes?

few weeks, many of you have written me asking if I could focus a few blogs on maintaining beauty during pregnancy. I completely understand. We are embarking on the holiday season, and while your concerns about how to stay healthy during pregnancy are tremendously important… we women also want to stay beautiful on the outside, while we grow a healthy baby on the inside.

There’s absolutely nothing wrong with wanting to remain attractive so, today, I am writing about stretch marks… one of those pesky skin conditions that may be avoided, or at least minimized, with proper care.

  1. What Causes Stretch Marks?
    Stretch marks are caused by the breakage of skin proteins during the rapid expansion of the skin during pregnancy. Stretch marks can appear on the abdomen, hips, breast, thighs, and underarms. Once formed, stretch marks are permanent. Various skin creams have been developed to try to reduce the appearance of stretch marks once formed. However, prevention should be the main goal since most of the other remedies intended to diminish their  appearance do not work.
  2. What are the important qualities of a good stretch mark cream?
    Remedies intended to prevent stretch marks mostly hydrate and moisturize the skin, thus allowing the existing skin proteins to stretch and not tear. However, a better approach is to INCREASE the skin collagen and elastin production giving much more distensibility to the skin.
  3. Is adding collagen to the ingredients sufficient?
    DON’T BE FOOLED!!—when certain products contain collagen in their ingredient list—this is not sufficient. The skin has to manufacture its own collagen and elastin for the product to work!!
  4. What ingredients should I avoid in choosing a stretch mark cream?
    There are several ingredients that should be avoided in pregnancy that are COMMONLY found in many of the popular brands.

    • PARABENS—This includes methylparaben  and propylparaben.
    • RETINOL—Vitamin A has in large doses has been associated with an increased risk of congenital anomalies. In addition, retin-A type products can be very irritating and cause rapid cell turnover so special precautions need to be taken with regard to the sun.
    • SODIUM LAURYL SULFATES AND SODIUM LAURETH SULFATE—Can cause dermatitis, skin and eye irritant, reports of toxicity in embryo development in animals
    • PHTHALATES—studies have shown that this interferes with the development of the male testes in animals.
  5. What ingredients are responsible for hydration and moisturization?
    Shea butter and various oils are responsible for the moisture and hydration. Unfortunately, most of the stretch mark creams for pregnancy ONLY have these ingredients and this is not sufficient to prevent stretch marks. The oils tend to make the product extremely greasy. Oils are nonabsorbent by the skin since water is a major component of skin cells. The oils tend to sit on the surface layers and stain clothing, especially in a large pregnant belly. In addition, the price points are also very escalated for these relatively inexpensive moisturizing ingredients.
  6. What other ingredients should I be concerned about?
    Alpha-hydroxy acid (AHA) is an ingredient commonly used in many creams. The purpose of this ingredient is to remove old skin and regenerate new skin—basically a mini-peel. This can be very irritating to many women. One must be very careful about going in the sun. AHA treatments are now undergoing scrutiny since there is a question of long term use of doing home chemical type peels. And the possible negative effects in the future.
  7. What makes the Beauté de Maman products superior?

Don’t Get Saddled With Periodontal Disease During Pregnancy

Monday, June 14th, 2010

I’m terribly sorry if anyone is offended by this photo of a horse with a bad set of choppers, but because a whopping 30% of pregnant women get periodontal disease, I simply couldn’t risk losing your attention. As they say, you can lead a horse to water, but you can’t make it brush its teeth.

While periodontal disease may seem like a boring and unglamorous topic for us to be discussing, it’s so important that I even decided to post two articles in a row about proper dental care during pregnancy.

My pregnancy article last week focused on dental changes, good oral hygiene and recommended dental health guidelines. This week’s pregnancy article will concentrate on the specific risks of periodontal disease. It’s not a pretty picture but please read all the way to the end to make sure you understand what you can do to stay out of the 30% and prevent this ugly and damaging syndrome.

What is periodontal disease?

Periodontal disease begins as gingivitis, or inflammation of the soft tissue that supports the teeth. This inflammation is caused by a specific oral bacteria named gram negative anaerobic bacteria. In combination with the elevated hormones during pregnancy that increase blood volume and capillary fragility, these bacteria give rise to redness, increased sensitivity, bleeding and pain. Left untreated, these conditions can predispose a pregnant woman to more serious problems down the road.

Why can periodontal disease lead to more serious problems during pregnancy?

If left untreated, the inflammation previously described can lead to the formation of pockets around the teeth. Within these pockets potential deep infections can occur and as pregnancy progresses, pocket depth has been shown to increase. These pockets are actually the separation of the teeth from the gums and, if left untreated, these teeth can separate from the surrounding supporting structure, named the periodontal ligament and cementum. This separation can eventually lead to the loss of the affected teeth.

What is the incidence of periodontal disease in pregnancy?

Approximately one third of all pregnant women have periodontal disease. Although the disease is measured differently in varying studies it is generally defined as 15 or more tooth sites with greater than 4 mm loss of attachment when probing.

Why is the presence of periodontal disease so important in pregnancy?

Periodontal disease has been associated with preterm delivery (before 37 weeks), low birth weight (less than 2500 grams), poor obstetrical outcomes, pregnancy loss, late miscarriage and preeclampsia, especially in populations comprised of people who have very limited access to dental care. Preterm birth rate has been reported to be 11.2% in women without periodontal disease compared to 28.6% in women with moderate to severe disease (Offenbacher, 2006). Similarly, progression of periodontal disease is also associated with a higher risk of preterm birth (6.4% vs 1.8% by same author). Most studies confirm these findings although some fail to show this association.

How can you explain this association of periodontal disease with poor obstetrical outcome?

  • One explanation is that bacteria or infection from the mouth enter the bloodstream and eventually reach the placental membranes causing inflammation and damage resulting in preeclampsia or labor.
  • Other explanations behind the results are that the specific bacteria and toxins identified in periodontal disease (Treponema denticola, Campylobacter rectus, Porphyromonas gingivalis to name a few) cause elevations in “inflammatory factors” or cytokines in the maternal blood (tumor necrosis factor-alpha, interleukin-8 (IL-8) and IL-1B) and it is these factors that have been found to increase the substances that stimulate the uterus to contract, such as prostaglandins (PGE-2), which cause the induction of labor.
  • Supporting this theory is the finding that blood from pregnant moms who have an increase in antibodies (reactive substances) to some of these bacteria found in the mouth have also been found to have a higher incidence of preterm birth and low birth weight infants. These same elevated antibodies have been found in amniotic fluid and in fetal cord blood samples of infants delivered preterm or of low birth weight.
  • Studies have shown that treatment for periodontal disease, through plaque control, scaling, and daily antibacterial rinsing reduced the risk of preterm births. Some studies however, have not been as consistent.

How does periodontal disease relate to other conditions in life?

After pregnancy, chronic exposure to these inflammatory blood substances from bacteria in the mouth may cause a three to four times greater risk later in life to cardiovascular disease, atherosclerosis, stroke, and diabetes compared to the general population. The mechanism is believed to be due to bacteria, toxins and platelets sticking together, along with circulating inflammatory factors which cause clots to form.

Children exposed to these inflammatory factors may also have added risk of cardiovascular disease and diabetes later in life. Other diseases associated with these inflammatory mediators include Crohn’s disease and Alzheimer’s disease as adults.

Summary

Periodontal disease is a curable problem. Treatment may not only help save your teeth, but will support the prevention of perinatal mortality and morbidity. If mothers are educated to realize that there might be a link between preventing periodontal disease and improving the health and well-being of their infant, not to mention their own health, more women will seek preventative dental care during pregnancy. Studies that are more conclusive with controls for socioeconomic status, smoking and study size have yet to be performed. However, even if the associations with these other factors are found not to be a factor in getting the disease, treating periodontal disease in pregnancy is safe and effective and, at the very least, may prevent unpleasant symptoms and appearance.  It may also prevent the need for costly treatment and potential tooth loss later in life.

You may want to stick my photo of the gingivitic horse on your refrigerator as a reminder to always take good care of your teeth, especially while you are pregnant. Please share this article with everyone you know who is pregnant or may get pregnant. We have provided some sharing links below.

As I mentioned last week… no one has ever regretted taking good care of their teeth!

Preeclampsia May Indicate Future Hypothyroidism

Wednesday, June 2nd, 2010

Pregnancy is like a fortune cookie for hypothyroidism.Last week I wrote about diabetes during pregnancy and how this gestational disorder can predict the development of the full blown disease later in life. A few weeks before this article, I wrote about preeclampsia, another pregnancy specific disease characterized by sudden onset of hypertension, protein in the urine and swelling. I stressed how preeclampsia can be associated with an increased future risk of hypertension and heart disease.

Now that you understand (from these previous blogs) that pregnancy sometimes serves as a “crystal ball” of future diseases in the mother, I want to give you another heads up. This time it’s about thyroid disease.

Thyroid disease is an endocrinological disorder that often manifests itself initially during pregnancy. It is the second most common endocrine disorder for women of childbearing age. In the general population, approximately 4% to 10% of non-pregnant women have sub-clinical hypothyroidism.

What is subclinical hypothyroidism?

The production of thyroid hormone is regulated by the pituitary gland in the brain which secretes thyroid stimulating hormone (TSH). This hormone travels to the thyroid gland and stimulates the production of thyroid hormone. When a patient has increased TSH in conjunction with a thyroid hormone level within the normal range, this is often referred to as “subclinical hypothyroidism.” It is generally considered to be an early stage of hypothyroidism. Overt hypothyroidism develops when a patient develops low thyroid hormone levels along with an elevated TSH level. The stress that pregnancy places on the entire body can cause a an improvement of an existing thyroid condition or cause a “silent” thyroid disease to reach a level at which it needs attention. This is often caused by antibodies developed by the body (auto-antibodies) against the organ. We are immediately concerned about this because women with latent thyroid disease during pregnancy have a higher risk of miscarriage in both the first and second trimester. Minor decreases in maternal thyroid levels have been associated with a lower IQ in the offspring. In addition, an association exists between pre-term delivery and thyroid abnormalities.

What are the changes that occur in pregnancy?

The thyroid gland sometimes increases in size during pregnancy. Iodide levels decrease during pregnancy because of fetal use of iodide. Therefore, it is recommended by the World Health Organization that pregnant women take 200 micrograms per day as a replacement.

The level of thyroid stimulating hormone is generally decreased in the first trimester, which has minimal clinical effects. TSH levels then normalize by second trimester.

How does preeclampsia effect the thyroid gland?

There is new consideration being given to the possibility that vascular damage after preeclampsia may affect the thyroid gland causing subclinical hypothyroidism. It has been proposed that this may be independent of the autoimmune process to which hypothyroidism is usually attributed.

In preeclampsia, the serum concentration of thyroid stimulating hormone is increased. This may cause subclinical hypothyroidism. Studies have shown that TSH levels sometimes increase 2.42 times above baseline in women with preeclampsia. Studies of women with preeclampsia have shown that those women are also more likely than a control group of women who do not have preeclampsia, to develop a raised TSH concentration about 20 years later. This raises the possibility that subclinical hypothyroidism is more common after preeclampsia and that women with a history of preeclampsia may even have an elevated risk of reduced thyroid function as they get older.

These thyroid findings may also contribute to the hypertension and coronary artery disease that has been found to occur in people who have had preeclampsia. Treatment with thyroxine may possibly reduce future cardiovascular risk. It may be advisable to screen women who have had preeclampsia for thyroid function after they deliver, with ongoing follow-ups. Treatment with thyroxine may prove to be beneficial in the prevention of early cardiovascular disease in affected women.

SUMMARY:

Preeclampsia can cause reduced thyroid function during pregnancy and can be an indicator of which women would be more prone to developing reduced thyroid function in later years. Women who have had preeclampsia are advised to be followed by the their physicians after their pregnancy has ended.

Stay healthy, all you mothers out there! Pay attention to what your pregnancy tells you.

Strung Out On Caffeine During Pregnancy?

Monday, February 15th, 2010

A Stimulating Summary of the Latest Research on Caffeine and Pregnancy

High test or decaf?

There is no question that many of us love our morning cups of coffee, or tea. Caffeine wakes us from our slumber and helps us become alert for the challenging day ahead. The true question, which is very important for a pregnant woman to understand is why, and how, caffeine affects the mother’s body—and the subsequent influence of that cup of coffee, tea or hot chocolate on her unborn child.

Products that contain caffeine, such as coffee, tea, and chocolate are amongst the most popular and widespread products consumed in the world and its usage may date as far back as 3000 BC, in China. While caffeine is known to be a natural pesticide that paralyzes and kills insects feeding on certain plants, its sustained popularity stems from several unique physiologic and pharmacologic properties. In other words, caffeine contains chemicals that have a profound stimulating influence on the nervous system, as well as many other human bodily functions.

Caffeine’s stimulant properties may:

 
What happens to the baby when a product containing caffeine is consumed?

Caffeine is absorbed by the stomach and small intestine within 45 minutes of ingestion. It crosses readily to the placenta, accumulating in both the fetus and amniotic fluid. It is metabolized three times more slowly in pregnant women compared to non-pregnant women, allowing for greater, and longer lasting, accumulation in the fetus.

Caffeine also significantly decreases blood flow in the placental villi, (small projections which help increase absorption of nutrients) through constriction of the vessels. Keep in mind that the fetus gets everything it needs from blood flow including nutrition, oxygenation, etc. and, if these vessels become constricted, the fetus gets less of everything needed for growth and development. Consequently, it is thought that maybe this constriction can possibly lead to reduced growth and can be associated with impaired development later on in life—or even stillbirth.

Considering the quantity of caffeine consumed, knowing whether caffeine is harmful in pregnancy is a major public health concern. Many studies have been written about the safety of caffeine in pregnancy most concluding that no malformations have been attributed to caffeine consumption and that most scientists believe that caffeine is not a teratogen (an agent or factor that causes malformations in an embryo) in humans.

However, concerns regarding harmful effects have stemmed from animal and human studies that have shown decreased intrauterine fetal growth, lower birth weights (less than 2500 grams), and skeletal abnormalities. (Vlajinac,1997;Caan, 1989). Other studies have shown no association between caffeine use and adverse outcomes in pregnancy. (Linn, 1982;Bech 2007, Clausson, 2000) Results of these kinds of studies are always questionable because many have been retrospective studies; those being studies that depend upon patient recollection, vary in the amounts of caffeine consumed, have differing sources of caffeine (coffee, tea, chocolate, medication), and have different methods of preparation and serving sizes.

Other studies have correlated specific quantities of caffeine consumed as being the determining factor of risk. (Fenster,1991)

It is known, however, that caffeine is readily transferred into human milk and therefore breast feeding mothers, who consume caffeine, may cause stimulatory effects in younger children.

In 1980, the United States Food and Drug Administration advised pregnant women to avoid caffeine containing foods and drugs, or use them sparingly.

The UK Food Standards Agency has recommended that pregnant women limit caffeine intake to under 200 mg of caffeine per day, which is equivalent to 2 cups of instant of coffee.

In Summary:

Most recent studies conclude that caffeine intake during pregnancy does not impose a major public health issue with regard to fetal health. However, because of the controversy that exists with the use of caffeine and impaired fetal growth in pregnancy, it is probably advisable to reduce the intake of caffeine during pregnancy to under 300 mg/day (3 cups of coffee) and encourage drinking decaffeinated coffee as a substitute.

Estimates of caffeine intake that might be helpful for pregnant women: (150 ml portion)

Coffee Tea Soft Drinks Cocoa
Brewed 115 mg Loose 39 mg 15 mg 4 mg
Boiled 90 mg Tea bags 39 mg    
Instant 60 mg Herbal 0 mg    

 
Dark roast has less caffeine compared to light roast because roasting reduces the caffeine content.

Tea generally contains more caffeine than coffee but is generally brewed much more weakly.

1 g of chocolate bar = 0.3 mg caffeine.

Most drugs contain 50–100 mg of caffeine per tablet.

Don’t Let Your Happy Pregnancy be Spoiled by Depression

Monday, October 19th, 2009

Depression in PregnancyDepression occurs in about 14–23% of all pregnant women. It is essential that we know how to make the diagnoses, when to treat, and the safety profile of the various drugs in managing this disorder. A recent landmark review was published by The American College of Obstetrics and Gynecology and the American Psychiatric Association that reviews the current guidelines.

Should I take an antidepressants if I am thinking of becoming pregnant?

Women with minimal or no symptoms for 6 months prior to conception, should contemplate tapering and discontinuing medication before conception. Behavioral therapy treatments can be used instead of medication.
Women with moderate to severe symptoms on medication should have their psychiatrist continue and optimize their medication prior to conception. The safety profile of the medications used should be carefully evaluated. Newer medications for depression and psychosis should be avoided if safety profile is not available.
Other conditions such as substance abuse, anxiety disorders, and eating disorders should be addressed at the same time.

What is the relationship between maternal depression and pregnancy outcomes?

Results from studies on miscarriage, growth effects, preterm births, and developmental delay with depression and use of antidepressant medication is severely limited due to poor studies and lack of consistency in conclusions. However, there was some evidence of an association of maternal depression and increased irritability, less attentiveness and activity, and fewer facial expressions in the newborn infant.

What is the safety profile of some of the commonly used antidepressant medication?

Tricyclic antidepressants-(Elavil, Norpramin, Pamelor, Aventyl, Anafranil, Tofranil, Evadyne)

Most studies have shown no association between the use of the tricyclic antidepressants and structural malformations. There was an increased association with newborn complications such as jitteriness, irritability, and occasionally convulsions.

Serotonin reuptake inhibitors (examples include Prozac, Celexa, Paxil, and Zoloft)

Some studies have shown a higher risk of cardiac malformations when SSRI’s were used during the first trimester, although the risk is considered very low and does not yet warrant the recommendations that women should not take these drugs. Combinations of different SSRI’s seem to have an even greater risk profile. However, other factors might be contributing to the results including obesity, diabetes, alcohol, and tobacco use. Some studies have shown evidence of rapid breathing, low sugar, temperature instability, irritability, weak cry, lower Apgar scores, and seizures in infants exposed to SSRI’s, especially in late pregnancy. Especially concerning were some reports of persistent pulmonary hypertension and respiratory distress. This can result in right heart failure.

Other antidepressants (Wellbutrin and Zyban, Effexor, Cymbalta, Remeron)

Fewer studies have been done on these agents but no increased risk of congenital anomalies or stillbirths have been found. There was a higher rate of newborn symptoms such as respiratory problems, low Apgar scores,hypoglycemia, and neonatal convulsions compared to women on no medications.

Electroconvulsive therapy

Severe depression that is unresponsive to medication can be treat with electroconvulsive therapy and does not harm the mother or the fetus.

Summary:

In conclusion, treatment of depression in pregnancy is based upon the risk of untreated mental illness in the mother versus risk factors to the fetus with the use of medication. The approach to decision making should be based on multiple factors including the severity of the disease, risk of relapse by stopping medications, response to therapy, social support, and recommendations on the part of the psychiatrist.

Vitamin D Deficiency and Pregnancy

Tuesday, July 28th, 2009

What is Vitamin D?

Vitamin D is a fat-soluble vitamin that plays a central role in calcium and phosphorous metabolism, which is critical for bone formation and maintenance.

Why is Vitamin D important?

morning-sickness-supplement
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Circumcision — The Cutting Edge

Wednesday, May 20th, 2009

The debate over circumcision is centuries old. Worldwide, about 25% of males undergo this procedure. In the United States, over 60% of males are circumcised. New evidence has recently emerged that brings forth additional benefits of this procedure, making it more appealing to new parents.
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Have a happy, healthy and Beauté de Maman pregnancy.

Saturday, May 2nd, 2009

Being an obstetrician, I have the greatest job in the world. Pregnancy and delivery is undoubtedly one of the supreme highlights in a woman’s life and I have the distinct pleasure of being able to share this moment with my patients on a daily basis.
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