Archive for the ‘Infant Safety’ Category

Cesarean on Demand

Wednesday, May 12th, 2010

Birth of Julius Caesar. Unknown artist. British Library

My mothers-to-be are astonishingly different from one another as they arrive ready to give birth in all possible shapes, sizes, and stages of delivery. Yet, in another way, they are mostly of one mind… determined to do anything medically necessary for the well-being of their baby.

Fortunately, the majority of births are pleasantly routine and everyone goes home a bit sore, but happy, healthy and determined to be a successful family. Once in a while, a delivery that may seem quite routine at first, can suddenly become complicated for any number of reasons. If the problems become overwhelming, the OB/GYN will strongly suggest that the parents give their consent for delivery via cesarian section, commonly known as a C-section.

This decision should not be suggested lightly because, after all, it’s surgery! Only after the OB/GYN deems that the risks of a C-section are lower than the risks of a vaginal delivery should the C-Section option be chosen. Safety for the mother and baby always come first and only the physician is trained to know when this procedure is medically necessary. In rare cases, parents may be told ahead of labor that a C-section will be medically necessary, (i.e. if the child did not turn around in the womb). This is not considered elective because the need for surgery is decided in advance.

After delivering more than 3,000 babies, I thought I had heard it all! That is until quite recently when we OB/GYNs began hearing a more puzzling kind of medical request—and began hearing it more and more often.

A case history
B.P. is a 40 year old professor of obstetrics from a major university hospital who is admitted to labor and delivery at term contracting every 5 minutes for the last hour. This is her first child—having been conceived through in-vitro fertilization. She is a healthy woman with no medical problems, has had a completely uneventful pregnancy with all routine prenatal testing showing normal results, appropriate fetal growth, adequate amniotic fluid, baby in a perfect head down position, and a recent ultrasound estimating the baby to weigh approximately 7 pounds. On admission to the delivery floor she requests an elective cesarean section.

It has been established that an individual has the right to refuse medical procedures, but does it also follow that a person has the right to demand a medically unnecessary treatment?

C-section Trends
Obstetrical care throughout the world is undergoing dramatic changes. Cesarean deliveries are increasing to the extent that in some countries, such as China and parts of Latin America it is well over 50%. There have always been certain traditional reasons for performing a cesarean section but recently “maternal request” has been added as a new indication. The rate of elective cesareans in the United States is now estimated to be between 4 % and 18%.

Reasons for elective C-sections

Fear of labor—(tocophobia)
Some women have a fear of pain, fear of an emergency and/or having to undergo a traumatic experience involving higher morbidity and mortality associated with complications.

Maternal convenience
Scheduling takes into account childcare, work concerns, support systems, choice of surgeon.

Prevention of maternal floor damage
Concerns about urinary or bowel injury or future sexual functioning resulting from traumatic vaginal delivery.

“Designer Baby”
Expensive reproductive technology needed for conception and the need to deliver in the least traumatic way to avoid any risk to the child.

Neonatal benefits
Elective cesarean is associated with lower newborn infection rates, lower risk of intracranial hemorrhage, neonatal asphyxia, and encephalopathy.

Prevention of any birth asphyxia or potential birth trauma
Avoidance of injury such as bone fracture, nerve injury.

Prevention of stillbirth
The need for preventing a stillbirth or overdue pregnancy with the inherent associated risks.

Sterilization
Doing a cesarean can allow for a subsequent sterilization procedure in some countries where reproductive rights are not available to women on request.

As obstetricians, we are faced with a difficult situation. Should a mentally competent patient have the right to choose, ethically, how they would like their baby delivered? While patients have the ability to make personal choices in many other areas of medicine, clearly this can not apply to obstetrics. Why? Because the lives of not one, but two humans, are at stake.

Are there viable disadvantages to an elective C-section?
Surgery always poses additional risk factors. Elective cesarean section has a 2.84 fold greater risk of a woman’s death than a vaginal birth.

Added risks include:

  1. Maternal morbidity
    This includes surgical injury such as damage to other organs, risk of hemorrhage, hysterectomy, infection, fever due to other causes, hematoma, anesthetic complications, and blood clots.
  2. Respiratory issues in the newborn
    Transient tachypnea (rapid breathing) of the newborn occurs more frequently after elective cesarean and respiratory distress more likely if the surgery is booked prior to 39 weeks.
  3. Potential complications with future pregnancies
    This includes increased risk of uterine rupture if laboring during a subsequent pregnancy if you have a uterine scar from a previous cesarean, increased risk of placenta previa (low lying placenta adhering to the scar), placenta accreta (placenta growing into a previous uterine scar), and placental abruption (separation of the placenta from the uterine wall).
  4. Complications from adhesions
    Surgery can lead to abdominal adhesions which might effect future fertility, causing chronic pelvic pain, increase risk to bowel and bladder in future abdominal surgeries,and higher risk of ectopic pregnancies and miscarriages.
  5. Injury to the baby
    There is a 1.9% chance that a surgeons knife can accidentally lacerate the fetus when doing a cesarean. However, emergency cesarean sections after labor has a greater incidence of lacerations compared to elective cesareans.

What is the answer?
In today’s day and age, is it acceptable practice to allow the patient to determine the medical decision, assuming she is competent and well informed of any additional risks she is placing on herself? (i.e. informed consent) Could a physician be at risk for denying a patient’s request for a cesarean if, postpartum, the procedure results in injury to herself, or her child, immediately or several years down the road?

It behooves the obstetrician, or midwife, to weigh all the risks and benefits of providing this option after exploring the reasons for the request. The ethics committee of Gynecology and Obstetrics (FIGO) states “Only the woman can decide if the benefits to her of a procedure are worth the risks and discomfort she may undergo.” We must respect the rights and autonomy of a mother. However, “performing cesarean section for non-medical reasons is not ethically justified.”

The American College of Obstetrics and Gynecology, however, feels that after exploring the request and proper counseling with informed consent, the physician can comply with the patients request if it is felt that cesarean will promote the overall health of the patient and the fetus more than a vaginal delivery.

This ethical controversy will continue to plague us, especially with health care costs spiraling. Having patients elect to have more expensive procedures, can threaten the solvency of the larger community. Why? Because a C-section requires not only a surgeon and an assistant, but an anesthesiologist, additional nursing, added supplies, equipment, an operating room, possibly blood for transfusion and longer hospitalization stays for both mom and baby.

We must ask ourselves if it makes sense to utilize the valuable time of medical professionals, as well as the financial resources of a community, in order to accommodate a woman’s desire to have the more expensive, and luxurious, C-section delivery?

Does respect for the rights of an individual outweigh the allocation of resources within a community? Right now, I personally don’t have the answer. I just want all my babies and mothers to leave happy and healthy.

Please let me know your thoughts below. I would be very happy to hear your opinion or to answer your questions regarding C-sections.

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To Clamp or not to Clamp… “When?” is the Question

Tuesday, March 30th, 2010

There are a million and one things to think about before arriving at your medical facility to deliver your baby. You may want to think about your La Maze exercises or if all your favorite songs are on your iPod. But, there is one thing you should think about long before you leave your house with contractions.

Clamping

I believe clamping of the umbilical cord is a conversation all pre-parents should have with their OBGYN early on during pregnancy. I speak to my patients about this because the outcomes of the timing are so important. Why? Because clamping of the umbilical cord not only has important implications for the newborn infant… but because both mothers and infants can be affected positively or negatively. That’s why there is an ongoing debate between doctors and midwives regarding the benefits and risks of the appropriate time to cut and clamp the umbilical cord. This argument generally refers to clamping within the first 15 seconds of life or to delay clamping as long as one to three minutes after birth.

Below is a summary of the literature regarding the pros and cons of immediate vs. delayed clamping of the cord.

What are some of the advantages of delaying the clamping of the cord?

  1. Reduces the incidence of anemia in the newborn.
  2. Hemoglobin concentrations remain elevated for 2 to 4 months after birth.
  3. Iron stores are increased for at least 6 months after birth.
  4. Fewer infants need blood transfusion.
  5. Studies of very low birth weight infants showed some protection against intraventricular hemorrhage (bleeding into a baby’s brain), late onset infections, and prevention of motor disability especially noted in male infants.

Facts:
A delay of even 30 to 45 seconds in cord clamping, especially in preterm infants can provide more blood volume and improve cardiovascular stability. By delaying even 30 seconds, blood volume can increase by 8 to 24% (2–16 ml/kg at cesarean section or 10–28 ml/kg after vaginal birth). In preterm infants , this can be critical in increasing blood pressure, establishing higher hemoglobin levels which can transport more oxygen to the tissues resulting in fewer days on a ventilator, fewer transfusions, lower rates of intraventricular hemorrhage, fewer cases of necrotizing enterocolitis (death of bowel tissue), and fewer cases of bronchopulmonary dysplasia. (chronic lung disease of newborns).

The theory behind this is that immediately after birth, the infant must increase the heart’s output to the lungs dramatically which requires adequate blood volume. If the cord is clamped too soon, not enough volume is present so the body must “borrow” it from other areas of the body such as the brain and the gastrointestinal tract and the lung itself resulting in lower blood flows in these areas with potential damage occurring. This damage can result in increased morbidity, mortality, and developmental delays. By delaying the clamping of the cord, the additional amounts of blood can stabilize blood flow to the brain and these vulnerable tissues, and increase the oxygen supply preventing infections and damage to these organs.

What are some of the disadvantages of delayed clamping of the cord?

  1. Polycythemia—hyperviscosity (large increase in packed red cell volume which can result blood clots or possibly stroke.)
  2. Higher peak bilirubin concentrations requiring possible treatment with phototherapy.
  3. Increased risk of maternal blood loss while waiting for clamping of the cord.
  4. Possible delay in resuscitation of the infant if needed (less than 10% of infants need resuscitation) causing respiratory distress.

Facts:
Studies have shown that although babies can have more packed blood volume from the delay in clamping of the cord, no adverse consequences have resulted from this. In addition, none of the infants studied had any increased risks of respiratory distress, or increased need for intensive care or length of hospital stay. Some infants had an increase in serum bilirubin causing jaundice requiring phototherapy at birth. There was no increased risk of maternal bleeding by delaying the clamping of the cord.

How is blood volume in the infant changed by the delay and position of the newborn after birth?

The total fetoplacental blood volume is about 120 ml/kg of fetal weight. The distribution of blood between the fetus and the placenta is 2 to 1 which remains the same if the cord is clamped immediately. Delayed cord clamping can result in an extra 20 to 40 ml of blood per kilogram of body weight to the fetus which is also an extra 30 to 35 mg of iron. By delaying 3 minutes, these higher infant blood volumes are obtained, especially if the infant is held about 10 cm below the level of the placenta. By holding the infant even lower, at about 40 cm, the placenta hastens blood transfusion to the infant to within one minute. Without lowering the infant, placental transfer of blood may fail to occur.

Summary:
Full term infants
Delayed clamping in the cord of full term infants is safe. Waiting for at least a minute, but preferably 3 minutes, before clamping the umbilical cord reduced the risk of neonatal anemia without incurring any major side effects in the newborn or the mother. Positioning of the baby should be on the mothers abdomen or lower. In poorer countries, where fetal anemia is common and often associated with higher mortality with impaired mental and motor development, delay in clamping of the cord can serve as a simple and very effective means of improving infant survival.

Oxytocin can still be administered after delivery to reduce maternal blood loss while waiting the three minutes for cord clamping. Use of oxytocin can also enhance placentofetal transfusion.

Premature infants
For premature infants , even a delay of 60 seconds with the infant lowered, can be critically important. Studies found no impact on risk of polycythemia, respiratory distress in the newborn, serum concentration of bilirubin, need for intensive care, length of hospital stay, or infants weight when clamping was delayed. Clamping the cord too soon can result in decreased blood volume in premature infants which can result in poor blood flow with reduction of oxygen delivery to parts of the premature brain resulting in enhanced possibility of motor damage and developmental delays. Also, the risks of postpartum hemorrhage (blood loss of 500 cc) was no different from delayed vs immediate cord clamping.

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Vaccinate Mom. Save the Baby.

Tuesday, March 23rd, 2010

My job as an OBGYN is to help make a woman’s pregnancy, and her baby’s birth, as smooth and wondrous as possible. This update may help you understand what to do about vaccinations during pregnancy and why your OBGYN will want you to be completely protected in order to protect your baby.

As a form of protection from acquiring certain serious diseases, women should be vaccinated. Unfortunately, pregnancy poses a special risk from vaccination because a developing fetus could acquire disease from a live virus or bacteria contained within the vaccine itself. It could result in a congenital birth defect. Therefore, only inactivated vaccines or vaccines containing toxoids (bacterial toxins that have been chemically altered) are generally recommended and administered during pregnancy. These immunizations are recommended when the risk of infection is high and when the vaccine is not live.

Recently, the American College of Obstetrics and Gynecology released a new statement regarding the administration of Tdap, (pertussis, tetanus, and diphtheria) for pregnant and postpartum women and their infants.

Their recommendations are as follows:

  1. Pregnant women who were NOT previously vaccinated with Tdap should receive the vaccine upon discharge from the hospital after delivery.
  2. All pregnant women should receive Tdap in the IMMEDIATE postpartum period before discharge from the hospital if the previous vaccination was greater than 2 years ago.
  3. The safety and efficacy of the pertussis vaccine has not been demonstrated in pregnancy and therefore it is not routinely recommended, except in the rare instance of a community outbreak. However, in cases where it was inadvertently given, there was no increased morbidity or mortality.
  4. All women thinking of becoming pregnant should be vaccinated.
  5. Adults and others in a household who anticipate contact with an infant less than 12 months old, are recommended to receive the vaccine.

In other words, get the vaccine, before you get pregnant if possible. If not possible get the vaccine after the baby is born and right before you leave the hospital.

What is pertussis?

Pertussis, or whooping cough, is a bacterial infection of the respiratory system caused by the organism Bordetella pertussis. The bacteria produces many toxins which damage respiratory epithelium and mucosal cells. Parents, and in particular new mothers, are a major source of infection for infants that are less than 12 months old. Unfortunately, this is also the age when fatalities are highest.

  1. Pertussis disease can range from a mild infection with no symptoms, to a prolonged severe illness sometimes lasting up to 6 months.
  2. Petussis is highly contagious, attacking 80 to 100% of individuals in a household that are not immunized.
  3. Pertussis is transmitted from person to person by coughing or sneezing.
  4. Pertussis in pregnancy is no more severe than for a non-pregnant woman.
  5. Most cases of pertussis present with spasms of whooping-like coughing, choking, post-cough vomiting and incontinence.
  6. Risks to the unborn child are relatively rare with no relationship to malformations in fetal development.
  7. Disease in adolescents and adults is marked by a prolonged coughing illness.

The biggest risk in pertussis is for infants that are less than 12 months old, especially within the first 6 months of birth. Complications, including death, are often due to coincident pneumonia that can involve other bacteria and viruses, and pulmonary hypertension (high blood pressure). Almost all infant deaths have occurred among unvaccinated infants.

Due to this fact, it is believed that vaccination of 90% of household contacts (children, adolescents, and adults) could prevent 75% of pertussis cases among infants between the ages of 0 and 23 months. In addition, vaccination of health care workers can prevent outbreaks in maternity wards, prenatal clinics ,and the nurseries in hospitals.

What is the incidence of pertussis?

The number of reported cases of pertussis has been increasing each year. There are worldwide cyclic outbreaks every 3–5 years. It is more frequent in the summer and autumn. Approximately 600,000 cases are reported each year in the United States and many milder forms are not reported. The majority of deaths occur within the first 3 months of life.

What is the treatment for pertussis?

A pregnant woman near term with documented pertussis can infect her child. Therefore, treatment with antibacterial agents and prophylaxis are essential in prevention of the newborn acquiring the infection. All members of the household including the newborn should be treated along with the infected person to prevent transmission to the newborn. Examples of antibiotics which are safe in pregnancy include erythromycin, azithromycin, or clarithromycin. For newborns, azithromycin is the preferred drug for newborns because of fewer side effects. Cough suppressants are generally not effective.

What is the latest information on the pertussis vaccine?

The pertussis vaccine’s protection lasts from 5 to 10 years. After this period of time people are again susceptible to the infection. The most common side effects from the vaccine include pain from the injection site, swelling and redness, headache, fatigue, and fever.

In summary:

Pertussis is a major cause of infant mortality and morbidity.

The CDC Advisory committee recommends routine vaccination for postpartum women before leaving the hospital, if they were not vaccinated in the past and have not been vaccinated in the last 2 years, in order to provide protection and prevent transmission of pertussis to their newborns.

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Reduce Baby Allergies Before Delivery?

Tuesday, March 16th, 2010

Oh Maybe, My Baby

Parents are persistent in asking their obstetricians, “Is there anything we can do when pregnant or breastfeeding to try and prevent allergies from occurring in our child? Why? Because Parents worldwide are noticing that the incidence of allergy, or atopy, in children is dramatically increasing. This includes asthma, allergic rhinitis (runny nose due to allergy), skin allergies (eczema), and food allergies.

Why is this increase in childhood allergies occurring and are there any nutritional options during pregnancy and lactation which will help prevent allergic disease?

In order to understand what to do, parents must first understand the severity and scope of the problem. This is what my research has uncovered.

What is the incidence of atopy (different allergies) in children?

It is estimated that 5-10% of children suffer from food allergies. Peanut allergy in particular is a growing public health problem effecting 1% of all British and US preschool children. The incidence has doubled in the past decade. Asthma incidence in the U.S. has increased 160% in children up to 4 years of age. Eczema is estimated to effect 10-20% of school age children and has increased 2 to 3 fold.

What causes atopic disease?

Atopic disease has a genetic basis but environmental factors, such as early nutrition, may also play an important role. Food allergy, eczema, and asthma are more likely to occur in infants with a family history of allergy in one or more first degree relatives. Chicken eggs, cow milk, peanuts, fish, nuts, wheat, and soy are the most likely foods that cause an immunologic reaction in childhood, many of which persist into adulthood.

Will altering maternal diet when pregnant prevent or delay atopic disease in children?

Here is what the American Academy of Pediatrics has recommended In the past.

Pregnant women avoid allergenic foods in their diet such as peanuts, eggs, and cows milk. However, recent evidence has NOT felt that dietary manipulations or restrictions make any difference. A large Cochrane review study done in 2006, involving 334 women, concluded that avoidance diets during pregnancy are UNLIKELY to substantially affect the child’s risk of atopic disease. In fact, such diets might adversely effect maternal or fetal nutrition which can cause lower gestational weight gain, slightly higher risk of preterm birth, and a reduction in birthweight of the infants. However, future trials with a larger sample size were recommended.

Similarly…

Another researcher, Muraro in 2004 after reviewing all the literature concluded that there is NO evidence that maternal diet during pregnancy or lactation prevents the development of atopic disease.

However, a study concludes…

A recent study by Soutter at the American Academy of Allergy, Asthma, and Immunology in 2010, involving 274 high risk pregnant women, each with a previous documented child with food allergies, showed that children whose mothers avoided certain allergenic foods during late pregnancy and lactation had a lower chance of developing asthma and allergic sensitization when avoiding peanuts, tree nuts, milk and eggs when examined at 18 months and 3 years of age.

By age 3, there was no significant difference between the groups for eczema symptoms and dust mite sensitization but the differences in rates of peanut and egg sensitization as well as asthma was large and significant. It is felt that avoidance behavior may work for certain people and not for others.

Does breastfeeding effect the development of atopic disease?

There is some evidence that breastfeeding in the first 3 to 4 months of life is associated with a reduced risk of developing allergic disease in early childhood, especially eczema during infancy and childhood asthma and wheezing.

As far as food allergy, breastfeeding for at least 4 months had a lower incidence of cow milk allergy in some studies but in others there was no difference. A Cochrane review from 2006 found that feeding an infant with a hydrolyzed formula compared to cows milk formula did reduce the the development of infant and childhood allergy.

There is no evidence that breastfeeding for greater than 6 months has any protective effect against allergic disease. The studies are controversial and mostly retrospective. Long term effects of breastfeeding on the development of allergy in later life is uncertain.

Why is the peanut allergy so common?

There are many theories as to why there is a rising prevalence in peanut allergies in western countries.

Peanuts are a staple of the American diet and is being used more commonly in “quick energy foods.” Considered excellent nutritionally due to its high protein content it is being ingested more frequently in pregnant and breastfeeding women (One peanut contains 200 mg protein). Peanut protein can be found in breast milk and in utero 1 to 3 hours after ingestion.

Most American children are exposed to peanut butter in their first year of life in contrast to other countries. Americans eat dry-roasted peanuts requiring higher temperatures, which increase the allergenicity. Other countries eat peanuts that are boiled or fried.

Even though the European guidelines and the American Academy of Pediatrics do not recommend avoidance of dietary allergens during pregnancy, the avoidance of peanuts during pregnancy might be an exception for families with a history of peanut allergy.

In summary:

At this time, current evidence does not support a role for dietary restrictions during pregnancy or lactation to prevent allergic disease. It is felt that more studies are needed.

For high risk infants with a strong family history of allergy, there is evidence that exclusive breastfeeding for at least 4 months compared with cow milk formula, decreased or delayed the risk of eczema, cow milk allergy and wheezing in the first 2 years of life.

For infants that are not breast fed but who are at high risk for allergy, there is some evidence that the use of hydrolyzed formula, compared to cows milk, helps prevent or delay allergic disease. Soy formulas are not recommended to prevent allergy.

Peanuts are the one exception where avoidance during pregnancy and breastfeeding may decrease the risk of subsequent peanut allergy.

Breast Feeding Experts Weigh in on SIDS.

Tuesday, March 9th, 2010


Back in November of 2009, I wrote a blog entitled Sudden Infant Death Syndrome;Vital Information Every New Parent Should Know. Under the section entitled Misconceptions about SIDS, I wrote that there was no evidence that breast feeding protects an infant from SIDS. This prompted a flurry of activity from some of the leading breast feeding experts in the world, who I am happy to say read my blog. Among some of the prominent individuals was Jennifer Matranga, RN, a past Chair and Member at large for the Connecticut Breastfeeding Coalition. I am extremely grateful that she was able to provide me with multiple recent articles correcting this information, which I would like to forward to my readers.

Articles that were cited were from FSID (Foundation for the Study of Infant Deaths in the UK) which is one of the leading baby charity organizations dedicated to preventing sudden deaths and promoting infant health. Their research showed that babies who were at least partly breast fed were one-third less likely to die of “cot death” than babies who were never breast fed. The USA Agency for Healthcare Research and Quality in 2007 also found that breast feeding reduced the risk of SIDS compared with never breast feeding and breast feeding should be recommended as a protective measure against SIDS.

Other studies found were from Pediatrics, March 2009 by Vennemann who examined 333 infants who died of SIDS with 988 matched controls and found that both partial breast feeding and exclusive breast feeding were both associated with a reduced risk of sudden infant death syndrome. The reduced risk was roughly 50% at all ages throughout infancy and therefore it was strongly encouraged to breast feed through the first 6 months of life.

In the International Journal of Epidemiology in 1993, a New Zealand Cot Death Study of 485 infants also showed a substantial association of breast feeding with a lowered risk of SIDS after controlling for other SIDS associated factors.

Why with so much evidence was there a statement made regarding the questionable relationship between breast feeding and the lowered risk of SIDS?

Some authors found a large increase in SIDS in certain countries but no parallel decrease in breast feeding during the same time frame. Many of the authors in the earlier literature have reported an increase risk of SIDS with bottle fed infants and other researchers have found no such effect. There are some researchers, using the same set of data who have reached conflicting conclusions.

SIDS is regarded as multifactorial in origin. An article by McVea in Journal of Human Lactation in 2000 reviewed the literature published between 1966 and 1997.The overall conclusion was that breast feeding is associated with a 50% reduction in SIDS risk but the quality of the studies varied. Many of the studies did not exclude other confounding factors such as socioeconomic status, exposure to cigarette smoke, maternal education, or sleeping position.

Other studies had different criteria for the diagnoses of SIDS and different time frames for breast feeding. Perhaps it was not breast feeding per se but the fact that babies who are breast fed have mothers that provide an overall healthier environment for their children in terms of skills, abilities, and emotional attachments. Breast feeding implies closer mother infant proximity with increased sensory contact and high responsitivity on the part of the mother—which may be the explanation for the decrease in SIDS. Perhaps it is the fact that breast feeding reduces the risk of infection in newborns which may explain the protective effect. Bacterial toxins may play a role in SIDS, and the presence of certain IgA antibodies found in breast milk may neutralize these toxins and provide a protective effect not found in bottle fed infants. Other explanations might involve the supine position as the universally chosen position for breast feeding mothers, which is known to be the optimal position in the prevention of SIDS.

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In summary:

Breast feeding is associated with a lower risk of post neonatal death. SIDS is the leading cause of mortality in infants 1 to 12 months in the United States.Recent studies have shown a relationship between breast feeding and a reduced risk of SIDS. It may be that breast feeding alone or a combination of other variables associated with breast feeding that may account for this finding. Current guidelines recommend breast feeding for a minimum of 6 months.

I wish to thank all those individuals who are reading my blog and helping me keep on my toes with the most accurate and up to date information for all pregnant women.

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They’re Stretching the Truth… Again

Sunday, February 21st, 2010

Beware of False Claims About Stretch Marks Creams

Pregnant Woman with Beaute de Maman

Beauté de Maman Stretch Mark Cream for pregnancy actually prevents the unsightly scars that many women get during pregnancy.

If you have ever gazed into the mirror after a pregnancy, only to see unsightly stretch marks covering your lower belly, breasts or thighs, you are not alone. Sadly, once women have stretch marks, it’s too late to do much about them because these types of skin imperfections can not be erased. They can only be prevented.

However, if you are pregnant now, or planning to become pregnant for the first time or again, you may want to read this article carefully.

The key to minimizing stretch marks before they occur requires knowledge of how your skin functions and knowing the truth about prevention.

  1. What Causes Stretch Marks?

    Stretch marks are caused by the breakage of skin proteins during the rapid expansion of the skin during pregnancy. Stretch marks can appear on the abdomen, hips, breast, thighs, and underarms. No matter what a product boasts, once formed, stretch marks are permanent. Various skin creams have been developed to try to reduce the appearance of stretch marks once formed. However, prevention should be the main goal because most remedies intended to diminish the appearance of stretch marks do not work.

  2. What are the Important Qualities of a Good Stretch Mark Cream?

    Remedies intended to prevent stretch marks mostly hydrate and moisturize the skin, thus allowing the existing skin proteins to stretch and not tear. However, a better approach is to increase the skin collagen and elastin production giving much more distensibility to the skin.

  3. Is Adding Collagen to the Ingredients Sufficient?

    Beware of false claims! Certain products do contain collagen in their ingredient list—but this is not sufficient. It is well known that the skin has to manufacture its own collagen and elastin for any product to go to work preventing stretch marks.

  4. What Ingredients Should I Avoid when Choosing a Stretch Mark Cream?

    Here are several ingredients COMMONLY found in many of the popular brands that should be avoided in pregnancy.

    • PARABENS: This includes methylparaben and propylparaben.
    • RETINOL: Vitamin A has in large doses has been associated with an increased risk of congenital anomalies. In addition, retin A type products can be very irritating and cause rapid cell turnover so special precautions need to be taken with regard to the sun.
    • SODIUM LAURYL SULFATES AND SODIUM LAURETH SULFATE: Can cause dermatitis., also a skin and eye irritant.
    • PHTHALATES: Studies have shown that this interferes with the development of the male testes in animals.
  5. What Ingredients are Responsible for Hydration and Moisturization?

    The shea butter and various oils are responsible for the moisture and hydration. Unfortunately, most of the stretch mark creams for pregnancy ONLY have these ingredients and this is not sufficient to prevent stretch marks. The oils tend to make the product extremely greasy. Oils are nonabsorbent by the skin since water is a major component of skin cells. The oils tend to sit on the surface layers and stain clothing, especially in a large pregnant belly. In addition, keep an eye on the price. Such products are commonly very expensive for these relatively inexpensive, moisturizing ingredients.

  6. What Other Ingredients Should I be Concerned About?

    Alpha-hydroxy acid (AHA) is an ingredient commonly used in many creams. The purpose of this ingredient is to remove old skin and regenerate new skin—basically a mini-peel. This can be very irritating to many women. One also must be very careful about being in the sun as sunburn can occur much more readily with this ingredient on the skin. AHA treatments are now undergoing scrutiny. There is a question of the effects of long term home usage of chemical peels with regard to potential negative effects on the skin.

  7. What Makes Beauté de Maman Products Superior to Other Brands on the Market?

    • Our Beauté de Maman product line does not exfoliate skin.
    • Beauté de Maman does not use acids to peel away skin.
    • In addition to our ultra moisturizing and skin softening ingredients,  we have included natural and herbal ingredients proven to help the skin manufacture collagen and elastin (Psium sativum, Bambusa vulgaris, Gardenia Tahitensis, and glucosamine HCL)
    • It is NOT a messy oil. Beauté de Maman stretch mark product is an absorbent cream that does NOT stain clothes.
    • Beauté de Maman has no odor.
    • Beauté de Maman is obstetrician created specifically for pregnant women.
    • Beauté de Maman has been pre-tested on hundreds of pregnant women and is safe for both mother and baby.

Finally, it is very important to me that Beauté de Maman remain affordable for ALL pregnant women. While our packaging is very pretty and feminine, our philosophy is to invest on the inside… bringing you safe and effective ingredients to keep your skin glowing and beautiful though out your pregnancy… and beyond!

Best regards,

Dr. Michele Brown, OBGYN

The Ten Inch Rule: How safe are airbags during pregnancy?

Monday, January 25th, 2010

As you know, airbags can save lives in car crashes, but many of my pregnant patients are very concerned about the risks involved to their unborn child if an airbag is deployed in an accident. Their concerns are warranted in that motor vehicle accidents present a greater risk to a fetus than to infants, or children. Why? Because while a child is vulnerable, that same child is physically independent from the mother. The fetus, on the other hand, relies on the placental connection for blood circulation which in turn provides all nourishment and oxygen necessary for survival in the womb. Any interruption or impairment of that connection places the fetus at high risk. While the uterine environment provides some protection to the fetus, we must remember that the fetus is living and totally dependent.

combo pack

Beauté de Maman Pregnancy Skin Care Combo Pack

Unfortunately, motor vehicle accidents (MVA) are the leading cause of fetal trauma in pregnant women, often resulting in fetal and maternal death. Approximately 2.8% of all pregnant women are involved in a motor vehicle accident, with the youngest age groups most affected. Reports of MVAs in pregnancy carries the risks of placental abruption (most common), low birth weight, prematurity resulting from premature labor, premature rupture of the membranes with loss of amniotic fluid and fetal death resulting from the direct trauma. Additionally, poor developmental outcomes, later in the child’s life, may be linked to the original trauma from a MVA.

One of our previous blogs discussed the use of seat belts and the evidence that suggests that seat belt use in pregnancy adds substantial protection to both fetus and mom. The American College of Obstetrics and Gynecology confirms improved safety of pregnant women wearing properly positioned seat belts. This newsletter will discuss the use of airbags, because knowing the optimal way to protect a pregnant woman in a car crash is of paramount importance.

Airbags and the ten inch rule.

Airbags have now become standard in all automobiles and have been reported to reduce death in non-pregnant motorists. However, the effect of airbags on those positioned too close to the airbag, such as children younger than twelve years of age, infants with rear facing car seats, the elderly, and short women can result in increased injuries and death. To avoid airbag injury, the National Highway and Traffic Safety Association recommends a minimum of a 10 inch distance from the center point of the airbag cover, (the plastic piece facing the driver) which is located either in the steering wheel or the dashboard, depending on the car model.

The safety and efficacy of airbags for pregnant women has not been clearly demonstrated. Since the gravid abdomen can be the leading point of contact from an airbag, especially in the second half of pregnancy, concerns about placental abruption, uterine rupture and direct fetal injury have been raised. It is extremely difficult to comply with the 10 inch safety distance from the airbag to the gravid abdomen, especially in the third trimester of pregnancy. However, it is still felt by the NHTSA that the use of airbags far outweigh the risks.

A recent study by Dr. Melissa Schiff in the January, 2010 article in Obstetrics and Gynecology, found no increased risk of maternal or fetal outcomes in front seat motorists involved in car collisions in which airbags were deployed. However, several other reports have demonstrated the reverse. Dr. Fusco, in the Journal of Trauma 2001, described a case of uterine rupture and fetal demise in a motor vehicle accident, possibly secondary to airbag deployment. Other reports (Schultze, 1998, Pearlman, 1996) described a case of placental abruption with fetal death associated with airbag deployment in a head-on crash. It is difficult to ascertain whether the impact of the collision or the airbag deployment is the cause of the uterine rupture or abruption. We must recall that there is a trade-off. Airbags may protect the mother from serious injury upon any impact with the dashboard or steering wheel.

Why is natural protection not enough protection?

Protection of the fetus from injury relies primarily on the cushioning effect of the amniotic fluid, the thick uterine musculature and the bony supporting structure of the pelvis. However, in a MVA, the placenta does not have the resilience to expand, contract and rapidly change shape with the traumatized rapidly shape-changing uterus, which explains why a shearing effect abruption occurs with rapid acceleration and deceleration forces. Obviously, crash severity affects the generation of fetal injury, but even relatively minor accidents, with speeds as low as 5 miles per hour can be associated with severe fetal trauma when the airbag is deployed at the standard expansion rate of 125 miles per hour.

Seat belts are still the first line of defense.

While further research needs to be done to support a definitive statement on the safety of airbags for the pregnant woman and the fetus, the best advice for now is to keep your belly at least 10 inches from the airbag cover, if possible. It is known, however, that shoulder and lap restraints prevent ejection from the car and forward movement of the mother in a front or rear-end collision, and therefore decrease maternal mortality and protect the fetus.

Make sure your seat belt is fastened. Unfortunately, there still exists a substantial group of pregnant women who do not wear seat belts, and when worn, do not wear them properly. Make sure your seat belt is positioned correctly. Seat belts decrease force transmission to the gravid uterus, but airbag deployment might contribute towards increasing force transmission to an anterior placenta resulting in an abruption, uterine rupture, brain hemorrhage, and skull fractures with consequent fetal demise. Another possibility includes the sheer impact of the collision causing these complications. Generally a protocol of monitoring a pregnant patient for at least 4 to 6 hours after a MVA has been adopted by most medical centers to detect whether traumatic injury to the fetus has occurred, as signs can be very subtle.

Summary

More research needs to be done that takes into account the gestational age of the fetus, the force of the collision, location of the placenta, and whether a seat belt was used in conjunction with the airbag. A definitive statement will have to await the outcome of such a  future study. I sincerely hope that my readers will be educated by this article and exercise caution, particularly in the second half of pregnancy. In other words, buckle up, remember the ten inch rule and please DRIVE CAREFULLY!

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Here is an update on an airbag study and pregnant women.

http://video.foxnews.com/v/3996144/car-safety-for-pregnant-women

The Tylenol Recall: Is Acetaminophen Safe to Use in Pregnancy?

Monday, January 18th, 2010

iStock_000001750203XSmallToday, I want to write to you about acetaminophen in pregnancy, a discussion that has been brought to the forefront by recent product recalls of Tylenol® and combination products containing Tylenol. This recall has baffled and confused my own patients, and many others, regarding the safety of swallowing this simple pain reliever. We should be especially careful now because we are still in the middle of a seasonal flu season including swine flu, which is especially risky for pregnant women.

The news is reporting contamination of a compound called 2,4,6-tribromoanisole. This seems to be the the result of a chemical produced when certain fungicides (mold inhibitors) are used to treat wooden pallets used to transfer products in the manufacturing plants. The health effects of ingesting and inhaling these contaminated products are unknown, but for the safety of both the mother and the fetus, pregnant women should be cautious and check the website www.mcneilproductrecall.com for specific batch lot numbers. We all need to be certain that contaminated capsules and gel tabs are NOT ingested in pregnancy.

The information below only pertains to Tylenol in its pure form, that which has NO evidence of any chemical contamination.

What should one do if pregnant and need relief of flu symptoms, fever, headaches, migraines, muscle aches and the like?

Acetaminophen is one of the most popular drugs used in America, and abroad, for reducing fever and for controlling pain. Vitamins are perhaps the only other prescription medication that are used more frequently by pregnant women. Acetaminophen is sold individually or in combination with decongestants and antihistamines in most common cold preparations and it is taken much more frequently than aspirin by pregnant women. Acetaminophen is also one of the most commonly overdosed drugs in pregnancy. Normal recommended dosage is 1,000 mg every 4 hours but acetaminophen in excessive doses can lead to liver toxicity and possibly fetal death because it is metabolized in the liver and readily crosses the placenta to reach the fetus.

Data on acetaminophen safety has been sparse until a recent published study, January 2010 in Obstetrics and Gynecology by Feldkamp, which collected data from the National Birth Defects Prevention Study. Telephone interviews were conducted with mothers of children with birth defects from 10 centers in the United States who delivered between January 1997 and December 2004 and used acetaminophen anytime from the first day of the last menstrual period through the first 12 weeks of pregnancy. Control groups were used for comparison. The study had limitations since it relied on accuracy of maternal memory regarding whether or not acetaminophen was used in the first trimester. The study also relied on maternal memory regarding the number of pills and dosage taken, which also could have a bearing on the the drug’s effects on the fetus.

Use of acetaminophen in the first trimester was found to be very common—averaging about 46%. Most importantly, the use of a single agent, acetaminophen, was NOT associated with any increased risk of birth defects. In fact, it was found that acetaminophen may DECREASE the risk of specific malformations that commonly occur in the first trimester when there is febrile (fever) illness in the mother. In particular, there was a decreased incidence of anencephaly, craniorachischisis, encephalocele, anotia or microtia, cleft lip with or without palate and gastroschisis. Other studies have shown that acetaminophen does not have any impact on fetal growth or preterm delivery.

Summary: Use of acetaminophen may have beneficial effects during a febrile (fever) illness when used as a single agent in the first trimester of pregnancy. Never exceed the recommended dosage.

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The Buzzzzz About Bug Bites and Babies

Monday, January 11th, 2010

Baby and MosquitoBaby, it’s cold outside but perhaps you are lucky enough to have a nice trip planned to someplace warm and romantic. If so, and you are  pregnant or traveling with a newborn and/or breast feeding baby, please take the time to read this warning about insecticides.

Pregnancy and Insecticide

Exposure to insect repellents has always been a source of concern with regard to adverse outcomes to the infant because they contain the chemicals DEET (N,N-diethyl-m-toluamide) or permethrin which can cross the placenta and are considered toxic in high doses. Generally 6 to 8 % of the repellent is absorbed when applied topically to the skin.

Studies in the past have shown that exposure of DEET to the skin of rats has caused developmental problems, low birth weight, and even death of the rat embryo. Exposure to DEET in chick embryos has caused cardiovascular malformations. Topical use of DEET by children has documented reports of toxic encephalopathy and anaphylactic reactions. Other previous studies in humans have shown minimal or no health risks or adverse pregnancy outcomes in the neurological, gastrointestinal, or dermatological systems with exposure to DEET.

Permethrin is another insecticide. It is sold as a 5% cream and is commonly used in the treatment of scabies during pregnancy. Similar controversies exist from reports of no reproductive effects to feminization of male rats.

A new study published in Occupational and Environmental Medicine by Nieuwenhuijsen in December 2009 reviewed 471 cases of hypospadias born to women in South East of England between January 1997 and September 1998. There was a significant association between the incidence of hypospadias and the use of insect repellents during the first trimester of pregnancy. In addition there was an association between multiple pesticide use and hypospadias.

Hypospadias is a common birth defect where the opening of the urethra (meatus) is on the underside of the penis. The incidence of hypospadias has increased with reported occurrences varying between 1 in 500 in the 1970’s to 1 in 250 in the 1990’s. The opening can be located in various places from the under-surface near the tip of the penis to to the base of the penis, or even behind the scrotum (more severe cases). Some cases can be genetic, some due to surgical injury, but some can also be environmentally associated. It can also be associated with other congenital anomalies. Children can have abnormal spraying of the urine, malformed foreskin, and often have to sit down to urinate. All male infants should be carefully examined by their pediatricians after birth for this condition since these infants should NOT be circumcised. The foreskin is commonly used for surgical repair.

In summary, a common congenital anomaly, hypospadias has been associated with insect repellents. Further studies are needed to delineate the type, and the mechanisms of action of pesticides in causing this problem. Because of the controversy regarding toxicity, recommendations have been to apply the smallest amount of insecticide on protective clothing rather than directly to the skin. It is also advisable that better protection from biting insects through use of long sleeved shirts and leg coverings be used. All male children should be carefully examined for this condition at birth.

Newborn, breastfeeding babies and insecticide

Researchers are still trying to connect the dots between disease, breathing problems and pesticides, but there is no reason to take any chances. Here are few alternative ideas to insecticide usage that both parents could follow when in an area prone to biting insects.

  1. Avoid taking yourself and your baby outdoors at dusk or dawn.
  2. Do not use scented soaps for bathing yourself or your baby, as they attract mosquitoes easily.
  3. When going outside dress yourself and your baby in lose and light colored clothing, and preferably full sleeved tops and pants.

If you must use a repellent with insecticide:

  1. Never spray insect repellent in an enclosed area. This might cause breathing difficulties for your baby.
  2. Never spray the repellent directly on the baby’s face. Instead, first spray the repellent on your hands and then apply to your baby’s face and exposed skin.
  3. Before trying any insect repellent for babies, apply a small patch on the baby’s arm to check if the baby’s skin is sensitive to it or not.
  4. Do not use insect repellent near the baby’s eyes, mouth and avoid applying the insect repellent on cuts.
  5. Avoid, using insect repellent on the baby’s hands as most babies have the habit of putting their hands into their mouth.
  6. Avoid applying the insect repellent on the baby’s skin more than once a day.
  7. Once you and your baby are back inside the house, wash off the insect repellent immediately with unscented soap and water.
  8. Never use insecticide on your breast or chest if you are breast feeding.

You can purchase out nipple gel at drugstore.com

Best regards,

Dr. Michele Brown,

OBGYN and Founder of Beauté de Maman

Lanolin and Breast Feeding. Bahhhd!

Thursday, January 7th, 2010
Lanolin comes from sheep and contains pesticides

Lanolin comes from sheep and contains pesticides

As you may know, most breast feeding women are sent home from the hospital, after giving birth, with a lanolin-based product to help relieve their sore, chapped nipples. As a physician and OBGYN, I am very concerned about this and want to send you this warning about lanolin based products.

The first thing you need to know is that pesticides have not one, BUT TWO, ways of getting into lanolin-based nipple gels and creams. It all begins with sheep—as lanolin comes from the sebaceous glands of these animals.

  1. Lanolin is an animal based product, 100% cholesterol, and is taken from sheep that graze on grass that is treated with pesticides.
  2. Sheep are often drenched with a chemical that prevents parasite infections. This chemical gets absorbed into the wool and oil glands of the sheep. After the sheep is shorn, the wool is sent to a special chemical scouring bath to separate the lanolin from the wool.

Once processed, lanolin is then concentrated and sold to companies that create creams, ointments, and cosmetics.

Several studies have demonstrated that there are residual pesticides in lanolin-containing compounds IN SPITE of purification by the companies that produce it.

This means that lanolin that is purified most likely will have residual pesticides both from the wool and from the grass that the sheep graze.

Therefore, when a new mother breast feeds using lanolin-based products, her infant may be getting trace amounts of these harmful chemicals. In addition, some women have wool allergy and will react to lanolin based products. Religious women who cannot have milk with animal products also cannot use lanolin. Lanolin is also a dark brown, greasy and smelly gel and is known to stain undergarments and bed linens.

I have developed an omega 3 fatty acid plant based, colorless and odorless gel with calendula officinalis. This herb is a well known remedy that is antibacterial, antifungal, and helps to prevent mastitis. This gel is moisturizing and soothing to the nipples and does not need to be wiped off prior to feeding. It is colorless and odorless and does not stain clothing.

All of my products have been pretested on hundreds of pregnant women and all ingredients have been carefully screened on physician only databases for safety. I have given out free sample packets to every delivered patient at Stamford Hospital with fantastic success and wonderful comments.

Happy breast feeding!
Dr. Michele Brown
OBGYN and Founder of Beauté de Maman

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Genetic Testing Risk Factors Reviewed

Monday, December 28th, 2009

Amniocentesis is a screening procedure performed by inserting a hollow needle into the uterus to sample amniotic fluid for genetic abnormalities.

Amniocentesis is a screening procedure performed by inserting a hollow needle into the uterus to sample amniotic fluid for genetic abnormalities.

Diagnosis of Birth Defects

Birth defects can occur in 3 to 5 % of all pregnancies and it is generally recommended that all pregnant women be offered some type of screening during their pregnancy. This early diagnosis is critical as it allows the physicians and the parents enough time to assess the severity of the condition and discuss possible alternatives of managing the pregnancy. In some cases treatment can be applied during pregnancy or immediately following the delivery. In other cases the defect is so severe that pregnancy termination may be an option.

Specific tests are now available to diagnose most birth defects early in pregnancy and to determine which test is best suited for an individual woman, a physician has to assess her specific risk. It is also important to recognize, however,  that most birth defects occur in woman who have no known risk factors. Although women over the age of 35 carry a higher risk of birth defects, the majority of children with birth defects are born to women under 35 due to the fact that this age groups bears more children. This younger group has not received proper attention in the past but with the advent of non-invasive testing, these women can now be screened quite safely.

Risk Factors for birth defects:

  • Mother’s age: Women over the age of 35 are at higher risk for both structural defects (i.e. heart defects) and chromosomal defects (i.e. Down’s Syndrome) birth defects. Younger women under the age of 20 have a higher risk of structural defects but not chromosomal defects.
  • Father’s age: Children of older fathers have a higher incidence of birth defects as well. In these instances the abnormalities are more subtle (autism, attention deficit disorder) and often difficult to diagnose before birth.
  • A history of a child with birth defects or a chromosomal problem.
  • A family history of birth defects or chromosomal problems.

Couples who fall into the high-risk group should be scrutinized more closely.

Diagnostic Tests

  1. Non-invasive tests (ultrasound and blood work) now allow for early detection of pregnancies at risk for birth defects and chromosomal abnormalities. However, more invasive testing such as amniocentesis and chorion villous sampling are used to reach a conclusive diagnosis. The non-invasive tests are therefore used to assess the woman’s risk and determine if the more invasive testing is needed. This relative risk is then used to determine whether amniocentesis is indicated. In this way, invasive procedures can be avoided in many circumstances. It also allows for safe screening for women who are not considered to be at risk based on their age and history.
  2. Invasive testing: Amniocentesis and chorion sampling. Both allow for accurate and reliable diagnosis of chromosomal defects but are also associated with a small but distinct risk of harming an otherwise normal pregnancy.

Non-Invasive Testing:

  1. Sequential Screening: This is a two part-screening test that is used to detect the following conditions.
    • Downs syndrome,
    • Trisomy 18,
    • Neural tube defects,
    • Abdominal wall defects, and other rare abnormalities.
    • The principle of this form of testing is to use several variables and measurements to assess the risk. The mother’s age, biochemical markers (blood tests), and ultrasound are used to determine the relative risk of birth defects. This approach increases the accuracy of detection.

    The sequential screen has 2 parts:

    1. Between the 11th and 14th week of pregnancy an ultrasound examination of the thickness of the fold on the baby’s neck, called Nuchal Translucency. The ultrasound exam and a blood test checking levels of two hormones markers, free B-HCG and pregnancy associated plasma protein (PAPP-A) are combined to improve the diagnostic accuracy. The combination of the tests allows Down’s Syndrome to be diagnosed over 80% of the time.
    2. Between 15 and 22 weeks measurements of the mother’s blood for another marker, AFP (alpha feto-protein) can increase the rate of detection of chromosomal abnormalities to over 90% and the neural tube defects to about 80%.
  2. Second Trimester Ultrasound: In the second trimester the baby’s systems have developed sufficiently for a careful ultrasound examination to allow detection of structural defects. Some of the structural defects are isolated (neural tube defects such as spina-bifida and anencephaly), and some are associated with chromosomal abnormalities—i.e. children with Down’s syndrome have a higher incidence of developmental heart and bowel disorders.

The optimal time for testing is between the 16th and the 20th week of pregnancy. An abnormal ultrasound then prompts more invasive testing to determine whether a chromosomal disorder is present as well.

Invasive Testing: Amniocentesis and Chorion Villous Sampling

  1. Amniocentesis
      Amniocentesis involves aspiration of a small amount of the fluid, which surrounds the baby. The fluid contains fetal cells, which can be analyzed for chromosomal, and biochemical defects. A needle is guided by ultrasound through the abdominal wall and into the fetal sac. A small amount of fluid is then aspirated.

      The test carries a low risk of pregnancy loss (1:300). Additional risks include fetal injury, infection, fetal bleeding, premature rupture of the membranes, and premature birth. The risk of these complications is also low.

      Amniocentesis is generally performed between the 14th and 16th week of pregnancy. Early amniocentesis (between 11 and 13 weeks) can be performed but carries a considerably higher risk of complications. It is therefore only done in special cases.

  2. Chorionic Villous Sampling (CVS)
      This procedure involves removing a small tissue sample from the developing placenta. It is performed between the 10th and 12th week. The sample is obtained using a needle and can be performed either through the abdomen (similar to amniocentesis) or vaginally through the cervix.

      Once obtained the tissue can then be analyzed for chromosomal defects.

      The advantage is CVS is that it can be done earlier than an amniocentesis. An early diagnosis allows for earlier and safer termination of pregnancy, if desired.

      The risk of CVS is similar to that of mid-trimester amniocentesis.

      However, alpha-fetoprotein assay still has to be performed at the usual time since, unlike amniocentesis—the protein cannot be measured at this time.

Summary:

Advancements in diagnostic testing lead to more accurate diagnosis of birth defects.

The improvement in the non-invasive tests allows:

  1. Testing of younger women considered to have an overall low risk of birth defects, and
  2. In older women who want to avoid the need for invasive testing and in those whose risk for birth defects appears to be low.

A team approach to the diagnosis and treatment of birth defect is essential. A genetic counselor, a perinatologist, a neonatologist and a psychological counselor can help the pregnant woman and her partner make informed decisions regarding the management of the pregnancy. The implications of the defect need to be reviewed with the couple along with the potential for treatment before and after birth.

In cases of severe defects the possibility of pregnancy termination should be discussed.

The emotional impact of these decisions for the parents cannot be overemphasized. Short term and long term follow up is essential.

Acne in Pregnancy

Friday, November 6th, 2009

Woman applying lotionSkin changes are one of the hallmarks of pregnancy. Oily skin and acne are common and often a source of discomfort, embarrassment, low self-esteem and depression.

The hormonal changes associated with pregnancy induce an increase in sebaceous glands secretion. This in turn creates fertile ground for the proliferation of acne causing bacteria (propionibacterium acnes).

Medical treatment of acne in the pregnant woman has to take into consideration the developing fetus. Many of the available drugs are either known to induce fetal abnormalities or have not been properly tested in pregnancy and therefore not recommended by the manufacturer. Examples include erythromycin estolate (which is associated with hepatitis), tetracycline (which can cause fatty liver atrophy in the mother and dental staining in the offspring), and Accutane or isotretinoin (which can cause a multitude of skeletal, cardiovascular, and craniofacial abnormalities). Even Retin-A, which works on skin cell DNA has a theoretical risk to the developing embryo and should be avoided, if possible.

Acne in pregnancy differs from that encountered in the teenager. The pregnant woman often presents with comedones, and papular lesions on the lower face, chin and jaw. These lesions are more often superficial. In contrast teenagers present with deep cystic lesions on the upper face and forehead and often contain pus. These differences dictate a different treatment approach.

In pregnancy, topical therapy is the preferred method of treatment of skin conditions. The absorption of drugs through the skin is minimal and in addition, more effective drug combinations can be better tailored to this particular type of acne.

If most of the lesions are comedones and superficial inflammatory papules, topical benzoyl peroxide or topical antibiotics can be used. For deeper lesions and cysts, it may be necessary to add an oral antibiotic.

Beauté de Maman’s mission is to develop products to combat the most common problems in pregnancy and address the lack of safe and effective remedies to treat these conditions. The hesitation on the part of pregnant women and their obstetricians to recommend treatment is often a result of their concern with the existing products, their safety in pregnancy, and the feeling that pregnancy is a temporary state not requiring immediate treatment.

In this tradition we have developed our Facial and Body Cream and Facial Scrub.

Beauté de Maman’s Facial and Body Cream is a safe and effective herbal product for oily, blemished skin in pregnancy. The active ingredient, Melaleuca alternifolia (tea tree oil) is extracted from the Australian Tea Tree and posses topical antibacterial, antifungal, antiviral, and anti-inflammatory activity. Tea tree oil is also superior to topical antibiotics, which are commonly used to treat acne. Topical antibiotics can lead to the development of drug-resistant skin bacteria, which can prove difficult to treat.

Tea tree oil is superior to other products used to treat acne and compared to benzoyl peroxide and azelaic acid, tea tree oil is nontoxic and non-irritating. Also, in contrast to benzoyl peroxide, tea tree oil does not bleach clothing, bedding, and hair. Studies have shown tea tree oil to be equally effective to benzoyl peroxide in treating acne with fewer side effects. The onset of action is more gradual, making it ideal for use in pregnancy.

The drying effect of tea tree oil makes it ideal for treating the oily blemished skin typical of early pregnancy. To avoid excessive drying the tea tree oil is prepared in a moisturizing base. Beauté de Maman’s Facial Scrub with its exfoliating beads, was developed to provide proper hygiene and cleansing of the skin to help remove dead skin cells, dirt and make-up prior to using the Facial and Body Cream.

The combination of the Facial Scrub and Facial and Body Cream is a safe and effective approach to the problem of oily and blemished skin in pregnancy and helps alleviate the condition and thus prevent the long-term sequelae of acne such as deep facial scarring.

Severe or unresponsive acne should always be referred to a dermatologist for more intense therapy.

Sudden Infant Death Syndrome; Vital Information Every New Parent Should Know

Tuesday, November 3rd, 2009

Crib_and_parentswebSudden infant death syndrome, commonly known as SIDS, refers to the sudden unexplained death of an apparently healthy infant under the age of one. It is the most common cause of death in infants between the ages of one month and one year in developed countries. The risk in the United States is .57 per 1000 births. Families that have lost one child from SIDS have a higher risk of recurrence.

Interesting facts about SIDS:

  1. More common in boys than girls (60:40 ratio)
  2. Peaks between 2 to 4 months and generally occurs before 6 months of age
  3. Blacks, American Indians, and Native Alaskans have 2 to 7 times the risk over the national average
  4. Japan and Netherlands have the lowest incidence; New Zealand has the highest; USA and UK are intermediate risk
  5. Risk is declining worldwide
  6. Premature infants with low birth weights have four times the risk of SIDS compared to full term infants.

Risk factors for SIDS

  1. Sleep position
    Numerous studies have shown that the supine position reduces the risk of SIDS by a factor of 20. Both side position and prone position have similar risks and should be avoided.
  2. Maternal smoking
    Prenatal and postnatal smoking both increase the risk of SIDS. Findings show that smoking decreases lung volume and heart rates in the infant. Nicotine also causes detrimental effects on the infants ability to respond to low oxygen levels.
  3. Soft bedding and accessories
    Pillows, quilts, comforters, and porous mattresses all increase risk of SIDS. Infants should not sleep on a couch or armchair. The American Academy of Pediatrics recommends that infants sleep on a firm surface without accessories.
  4. Warm room temperatures
    Overheating of infants with multiple blankets, clothing layers, in a warm room increases the risk of SIDS, especially when infants are placed in the prone position.
  5. Bed sharing
    Co-sleeping increases SIDS risk especially for infants under 11 weeks of age, when the mother smokes, drinks, or is overtired and the infant shares the bed for the entire night. Half the infants who die of SIDS in the United States co-share beds. The ideal environment is in a crib or bassinet separate but near the mother’s bed.
  6. Pacifiers
    Risk of SIDS is reduced with use of pacifiers. These infants have been found to have improved ability to breathe with their mouth and have less of a chance of oropharyngeal obstruction.

What Causes SIDS?

The cause of SIDS is due to three important factors occurring coincidentally

  1. Vulnerable infant—the theory is that children that succumb to SIDS have abnormalities in their arousal system and are unable to compensate for low oxygen levels. This ability is controlled by certain parts of the brainstem and hypothalamus. There are probably genetic differences that involve serotonin transport activity in the brain and the autonomic nervous system.
  2. Critical developmental period—the child must be within the first year of life
  3. Exogenous source—an outside stress like prone sleeping or nicotine exposure.

What Are Some Misconceptions About SIDS?

  1. Apnea monitor—There is no evidence that they are useful in preventing SIDS
  2. Immunizations—There is no evidence that immunizations increase the risk of SIDS
  3. Breast feeding—there is no evidence that it protects an infant from SIDS

Conclusions:
SIDS is due to an interaction between genetic and environmental factors. Teaching parents safe sleeping practices for their infants is essential in reducing the risk of this disease. In particular, sleeping children on their backs, avoiding tobacco and alcohol use, avoid overheating the infant, sleeping children on a firm mattress in a separate bed without accessories , and use of a pacifier can reduce the risk of this problem.

Can Folate Prevent Neural Tube Defects in Your Baby?

Monday, October 12th, 2009

babyultrasound1

What are Neural Tube Defects?

Defects of the brain and spinal cord are referred to as neural tube defects. The most common defects are spina bifida, where the spinal column does not close, and anencephaly with failure of brain development. This occurs in 1/1000 pregnancies or approximately 3000 births per year.

Neural tube defect incidence can vary by region in the United States. The highest incidence occurs in the southeast portion of the country.

Is There a Way to Prevent NTD?

Investigators in many studies have shown that multivitamins containing folic acid can reduce the risk of NTD. Supplementation with folic acid can reduce the risk of NTD by 70% in women with no prior history of NTD and 50% in women that have had 1 previous pregnancy with NTD. However, not all NTD are related to folic acid but rather some may be related to genetic, immune factors, diabetes, or obesity.

What Foods are Good Sources of Folate?

Bread/rolls/crackers and other enriched grain products,legumes, leafy vegetables, liver, breakfast cereal, fruits and juices are all good sources of natural folate. Folic acid is a synthetic form of folate (vitamin B9) that is found in the multivitamins. Women of childbearing age should consume 400 mcg to 800 mcg of folic acid before conception and throughout the pregnancy. Women with a prior history of NTD should consume 4 mg daily. Generally, enriched grain products contain approximately 140 mcg folic acid per 100 g flour.

Overall, it has been found that less than 10% of women meet the daily requirement of 400 mcg of folate per day. Women on low carbohydrate diets and those with malabsorption syndromes are at increased risk of folate deficiency. In addition, certain medications prevent absorption of folate such as beta-blockers, calcium channel blockers,cimetidine, Bactrim (septra), and certain anti-seizure medications such as phenobarbital, phenytoin, tegretol ,primidone, and valproic acid.

The availability of folate from natural sources varies depending upon the food source and the way that the food is cooked. Therefore, supplementation is used in pregnancy to increase the availability of this vitamin. The body is unable to synthesize this vitamin and depends upon ingestion. Being a water soluble vitamin, excess amounts get excreted in the urine and excess consumption presents no known risks.

What is the Mechanism by which Folate Reduces NTD?

The mechanism of action of folate reducing neural tube defects is unknown. Some cases are independent and some are part of a syndrome of multiple other genetic anomalies. NTDs tend to occur more frequently in women that have a family history and also in couples that have had a previous child with this disorder.

The first 25 days of gestation are particularly important for ingestion of this vitamin since neural tube closure occurs from day 18 to day 26 of gestation. Therefore, preconception ingestion with adequate amounts of folate that the body stores is very important since the critical time for neural tube closure is so early.

Is Folate Important for Other Reasons in Pregnancy?

Folate is important for DNA synthesis, cell division, and amino acid metabolism. Folate is critical in the metabolism and reduction of homocysteine in the body which prevents cardiovascular disease. Folic acid is also believed to reduce the risk of cleft palate and other genitourinary anomalies.

Recommendations

Obstetricians and other health care providers of women in the reproductive age range should counsel their patients on the importance of folic acid supplementation during pregnancy. First prenatal visits commonly occur after closure of the neural tube so folic acid consumption should begin before conception and continue especially in the early stages of pregnancy. Proper counseling is especially critical in those patients with a previous history of NTD or a family history since recurrence risk is higher.

Beaute de Maman Morning Sickness Supplement

Beaute de Maman Morning Sickness Supplement

Beauté de Maman recognizes the importance of folate supplementation during pregnancy. Often women having severe nausea and vomiting in the first trimester of pregnancy can be at greater risk of folate deficiency. In addition to providing supplementation of folate through prenatal vitamins, controlling the nausea and vomiting of pregnancy with the Beauté de Maman’s natural dietary herbal supplement can help prevent having a deficiency in this important vitamin. The Beauté product contains ginger and Vitamin B6 as a first line natural remedy as per the American College of Obstetrics and Gynecology guidelines.

Newborn Obesity Diminished With Exercise

Monday, September 28th, 2009

Fetal obesity, commonly known as macrosomia isHealthy Preganancy defined as fetal weight above 4,000 grams or 8 pounds 8 ounces. There is an increasing trend worldwide towards heavier birth weights. Birth weight is an important predictor of morbidity, infant survival, later childhood size, heart disease and diabetes in later life.

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A recent study published from Norway by Obstetrics and Gynecology authored by Owe in the October 2009 issue has shown a direct relationship between exercising during pregnancy and prevention of excessive weight gain in newborns. Reduction of birth weight by regular exercise can be as great as 23–28%. The study followed 36,869 pregnant women prospectively till at least 37 Pregnant woman with swimming goggles in a poolweeks gestation. A history of diabetes and smoking did not effect the results. Women giving birth to their first baby who performed a high level of exercise were less likely to have overweight newborns. Women with previous children were more likely to have heavier babies but exercise on a regular basis still prevented macrosomia. Exercise performed before conception appeared to have no effect on birth weight but women who exercised before becoming pregnant were more likely to continue exercising during their pregnancy.

The mechanism behind the control of birth weight through exercise may involve glucose levels which are lowered with moderate physical activity in both diabetic and non-diabetic pregnancies.

In conclusion, obstetricians should strongly encourage pregnant women to exercise throughout their pregnancies. Recent trends have shown a decrease trend towards exercising in pregnancy—both in frequency and intensity, especially as the pregnancy progresses. Exercises also tend to shift from weight bearing to non weight bearing activities as one gets further along in the pregnancy. This study serves to emphasize the importance of continuing aerobic exercise during pregnancy to avoid many of the complications that occur to both mother and fetus from large babies. The maternal complications include lacerations, hemorrhage, increased possibility of cesarian sections, shoulder dystocia and other types of trauma associated with the delivery of large babies.

New Study Warns Against Prolonged Time in Car Seats for Infants

Monday, August 31st, 2009
Baby in Car Seat.

Baby in Car Seat.

Safe transportation of infants, both preterm and term, with the use of car seats and car beds is essential. Car seats and car beds prevent injury and death according to the National Highway Traffic and Safety Administration. However, previous studies have shown some respiratory compromise occurs in preterm infants placed in car seats. It has now been demonstrated in a study by L. Cerar from Pediatrics August 2009 that the same might be true of full term infants.

Two hundred newborns were evaluated on the second day of life by measuring oxygen levels and breathing patterns in car seats, car beds, and cribs. The same infants measured in each of the devices also served as their own controls. It was found that oxygen levels were significantly lower in both car seats and car beds compared to hospital cribs. In addition, even those infants that were able to compensate for the respiratory limitations initially were found to develop respiratory compromise with prolonged periods of time due to deeper sleep stages and more chest wall muscle fatigue.

The reasoning behind the findings is that there is some obstruction to the airway due to flexion of the head when an infant is placed in the car seat or car bed causing these lower oxygen levels. The other important factor is some compromise of the chest wall motion that occurs in the upright position even though the safety belt was standardized to allow for 1 finger width distance between the infant and the harness.

The conclusion from this important study is that parents should only use car seats and car beds for travel and not as a replacement for a crib. Infants should not be placed in these transport safety devices for prolonged periods of time. Finally, manufacturing companies should brainstorm on how to redesign these devices to eliminate the respiratory compromise that occurs when infants are placed in the upright position with flexion of the head for prolonged periods of time. Most pediatric specialists do not feel that the implications of this compromise is significant in the long run but others feel that even a mild amount of obstruction might be associated with behavioral problems and IQ deficits.